Blebbing of the plasma membrane of lymphocytes as a marker of endothelial dysfunction in the development of post-resection insufficiency in patients with focal liver lesions
https://doi.org/10.31146/1682-8658-ecg-216-8-110-115
Abstract
Purpose of the study. To evaluate the intensity of blebbing of the plasma membrane of lymphocytes and the formation of microparticles of lymphocytic origin in patients with postresection hepatic failure. Material and methods. The study involved 54 patients with focal liver diseases. The study involved 32 (59%) women, 22 (41%) men. The average age was 59.5 [49.75; 66,00]. Patients were divided into groups, 1 group - 10 patients with developed acute liver failure and 2 group - 44 patients with a favorable course of postoperative period. The following surgical interventions were performed: 36 (67%) patients underwent surgery - laparotomy, segmental liver resection, 10 (18%) - left-sided hemihepatectomy and 8 (15%) - right-sided hemihepatectomy. Results. Predictors of early postoperative hepatic failure are a decrease in initial blebbing and an increase in terminal blebbing and free microparticles of lymphocytic origin. Conclusions. Thus, changes in lymphocyte blebbing and the presence of free microparticles of lymphocytic origin are due to the development of endothelial insufficiency and apoptosis of lymphocytes in the context of liver failure and are determined by the reduced function of residual liver volume.
About the Authors
S. S. Dunayevskaya
Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
N. A. Malinovskaya
Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
A. A. Kosik
Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
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For citations:
Dunayevskaya S.S., Malinovskaya N.A., Kosik A.A. Blebbing of the plasma membrane of lymphocytes as a marker of endothelial dysfunction in the development of post-resection insufficiency in patients with focal liver lesions. Experimental and Clinical Gastroenterology. 2023;(8):110-115. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-216-8-110-115
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