Celiac disease — difficulties in making a diagnosis
https://doi.org/10.31146/1682-8658-ecg-214-6-185-190
Abstract
Celiac disease (gluten enteropathy) is a chronic genetically determined autoimmune T–cell-mediated enteropathy characterized by persistent intolerance to specific proteins of the endosperm of some cereals with the development of atrophic enteropathy and associated malabsorption syndrome.
Despite the growing interest in pathology, as well as the sufficient prevalence of the disease, this diagnosis often remains difficult to make.
The article presents a clinical case of an atypical form of celiac disease in a boy who was admitted to the hospital in a serious condition with a clinical picture of dynamic intestinal obstruction, which required extensive differential diagnosis.
Repeated laboratory tests (clinical, biochemical), instrumental methods of examination, including fi broesophagogastroduodenoscopy with biopsy material sampling followed by morphological diagnostics allowed us to conclude the presence of celiac disease in this patient.
About the Authors
D. A. Galova
Children’s City Clinical Hospital No. 1
Russian Federation
Russian Federation
Darya A. Galova, pediatrician, gastroenterologist of the pediatric department No. 4
76 Gagarin Ave., Nizhny Novgorod, 603081
E. V. Tush
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Privolzhsky Research Medical University
Elena V. Tush, pediatrician, hematologist, nephrologist, endocrinologist, Candidate of Medical Sciences, Associate Professor of the Department of Hospital Pediatrics
10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005
N. Yu. Orlinskaya
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Natalia Yu. Orlinskaya, MD, Associate Professor, Head of the Department of Pathological Anatomy
10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005
N. Yu. Shirokova
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Natalia Yu. Shirokova, Candidate of Medical Sciences, Researcher
10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005
K. S. Shiralieva
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Kubra Sardar Kyzy Shiralieva, a student of the pediatric Faculty
10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005
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Review
For citations:
Galova D.A., Tush E.V., Orlinskaya N.Yu., Shirokova N.Yu., Shiralieva K.S. Celiac disease — difficulties in making a diagnosis. Experimental and Clinical Gastroenterology. 2023;(6):185-190. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-214-6-185-190
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