Систематический анализ экспериментальной и клинической фармакологии никотинамида и перспективы лечения атеросклероза
https://doi.org/10.31146/1682-8658-ecg-206-10-111-125
Аннотация
Никотинамид (ниацин) - витамер РР (Pellagra-Preventive), необходимый для синтеза никотинамид аденин динуклеотида (НАД). Молекула НАД является коферментом белков, вовлечённых в синтез АТФ из жиров и углеводов. Более 50 лет никотинамид используется как антигиперлипидемическое средство и для улучшения микроциркуляции крови. Результаты систематического анализа 70417 публикаций по фармакологии никотинамида позволил уточнить молекулярные механизмы вазопротекторного действия никотинамида (в т. ч. противовоспалительного действия), суммировать результаты экспериментальных и клинических исследований антиатеросклеротических эффектов (включая лечение стеатогепатоза и противодействие ожирению) и кардиопротекторные свойства никотинамида. Показаны перспективы сочетанного применения статинов и никотинамида, которое позволяет снизить дозировки статинов.
Ключевые слова
стеотогепатоз,
ожирение,
кардиопротекция,
липидный профиль крови,
Лактофлорене Холестерол,
фармакоинформатика
Об авторах
О. А. Громова
ФИЦ «Информатика и Управление» РАН
Россия
Россия
И. Ю. Торшин
ФИЦ «Информатика и Управление» РАН
Россия
Россия
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Рецензия
Для цитирования:
Громова О.А., Торшин И.Ю. Систематический анализ экспериментальной и клинической фармакологии никотинамида и перспективы лечения атеросклероза. Экспериментальная и клиническая гастроэнтерология. 2022;(10):111-125. https://doi.org/10.31146/1682-8658-ecg-206-10-111-125
For citation:
Gromova O.A., Torshin I.Yu. Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis. Experimental and Clinical Gastroenterology. 2022;(10):111-125. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-206-10-111-125
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