nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-206-10-111-125nogr-2167Research ArticleОБЗОРREVIEWСистематический анализ экспериментальной и клинической фармакологии никотинамида и перспективы лечения атеросклерозаSystematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosishttps://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.noemail@neicon.ruФИЦ «Информатика и Управление» РАНРоссияFederal Research Center “Computer Science and Control” of the Russian Academy of SciencesRussian Federation202218012023010111125Copyright © Громова О.А., Торшин И.Ю., 20232023Громова О.А., Торшин И.Ю.Gromova O.A., Torshin I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/2167

Никотинамид (ниацин) - витамер РР (Pellagra-Preventive), необходимый для синтеза никотинамид аденин динуклеотида (НАД). Молекула НАД является коферментом белков, вовлечённых в синтез АТФ из жиров и углеводов. Более 50 лет никотинамид используется как антигиперлипидемическое средство и для улучшения микроциркуляции крови. Результаты систематического анализа 70417 публикаций по фармакологии никотинамида позволил уточнить молекулярные механизмы вазопротекторного действия никотинамида (в т. ч. противовоспалительного действия), суммировать результаты экспериментальных и клинических исследований антиатеросклеротических эффектов (включая лечение стеатогепатоза и противодействие ожирению) и кардиопротекторные свойства никотинамида. Показаны перспективы сочетанного применения статинов и никотинамида, которое позволяет снизить дозировки статинов.

Nicotinamide (niacin) is a PP (Pellagra-Preventive) vitamer necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). The NAD molecule is a coenzyme of proteins involved in the synthesis of ATP from fats and carbohydrates. For more than 50 years, nicotinamide has been used as an antihyperlipidemic agent and to improve blood microcirculation. The results of a systematic analysis of 70417 publications on the pharmacology of nicotinamide made it possible to clarify the molecular mechanisms of the vasoprotective action of nicotinamide (including anti-inflammatory action), to summarize the results of experimental and clinical studies of anti-atherosclerotic effects (including the treatment of steatohepatosis and counteraction to obesity) and the cardioprotective properties of nicotinamide. The prospects for the combined use of statins and nicotinamide are shown, which allows to reduce the dosage of statins.

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The authors declare that there are no conflicts of interest present.