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Экспериментальная и клиническая гастроэнтерология

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ЭПИДЕМИОЛОГИЧЕСКИЕ И КЛИНИКО-ГЕНЕТИЧЕСКИЕ ХАРАКТЕРИСТИКИ ПОРОКОВ РАЗВИТИЯ АНОРЕКТАЛЬНОГО ОТДЕЛА

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Аннотация

В обзоре представлен анализ современных данных по эпидемиологии, этиологии и клинико-генетическим характеристикам врожденных пороков развития аноректального отдела пищеварительного тракта. По данным международных регистров врожденных пороков развития популяционная частота АРП варьирует от 2 до 5 на 10000 рождений. Не выявлено изменения частоты аноректальных аномалий во времени (отсутствие временных трендов). В большинстве исследований отмечается преобладание мужского пола среди больных с аноректальными пороками (АРП). Примерно 40 - 70% пациентов с АРП имеют врожденные пороки развития других органов и систем. Представлены данные об участии генетических и средовых факторов в происхождении АРП. Дана краткая клинико-генетическая характеристика наиболее частых синдромов (ассоциаций) с АРП.

Об авторах

Ю. В. Выдрыч
ГБОУ ВПО Первый МГМУ им. И. М. Сеченова
Россия


Н. С. Демикова
ОСП Научно-исследовательский клинический институт педиатрии ГБОУ ВПО РНИМУ им. Н. И. Пирогова
Россия


Ю. Н. Филюшкин
ГБУЗ МО Московский Областной Научно-исследовательский клинический институт им. М. Ф. Владимирского
Россия


С. Г. Калиненкова
ГБУЗ МО Московский Областной Научно-исследовательский клинический институт им. М. Ф. Владимирского
Россия


М. А. Подольная
ОСП Научно-исследовательский клинический институт педиатрии ГБОУ ВПО РНИМУ им. Н. И. Пирогова
Россия


А. С. Лапина
ОСП Научно-исследовательский клинический институт педиатрии ГБОУ ВПО РНИМУ им. Н. И. Пирогова
Россия


А. Е. Машков
ГБУЗ МО Московский Областной Научно-исследовательский клинический институт им. М. Ф. Владимирского
Россия


А. Ю. Асанов
ГБОУ ВПО Первый МГМУ им. И. М. Сеченова
Россия


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Для цитирования:


Выдрыч Ю.В., Демикова Н.С., Филюшкин Ю.Н., Калиненкова С.Г., Подольная М.А., Лапина А.С., Машков А.Е., Асанов А.Ю. ЭПИДЕМИОЛОГИЧЕСКИЕ И КЛИНИКО-ГЕНЕТИЧЕСКИЕ ХАРАКТЕРИСТИКИ ПОРОКОВ РАЗВИТИЯ АНОРЕКТАЛЬНОГО ОТДЕЛА. Экспериментальная и клиническая гастроэнтерология. 2016;(5):58-64.

For citation:


Vydrych Yu.V., Demikova N.S., Filyushkin Yu.N., Kalinenkova S.G., Podolnaya M.A., Lapina A.S., Mashkov A.E., Asanov A.Yu. EPIDEMIOLOGICAL, CLINICAL AND GENETIC CHARACTERISTICS OF ANORECTAL MALFORMATIONS (REVIEW). Experimental and Clinical Gastroenterology. 2016;(5):58-64. (In Russ.)

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ISSN 1682-8658 (Print)