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Experimental and Clinical Gastroenterology

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Anemia and diseases of the gastrointestinal tract

https://doi.org/10.31146/1682-8658-ecg-200-4-20-32

Abstract

Anemias are often associated with the pathology of the digestive system. This literature review presents data on the etiology, pathogenesis, diagnosis and treatment of iron defi ciency, B12-defi ciency, folate defi ciency anemias, as well as anemia of chronic diseases and autoimmune hemolytic anemias associated with diseases of the gastrointestinal tract.

About the Author

S. A. Vorobyev
Tver State Medical University, 4
Russian Federation

Sergei A. Vorobyev, Associate Professor at the Department of Faculty Therapy

Sovetskaya St., Tver, 170100



References

1. Luzina E. V., Lareva N. V. Anemia and gastrointestinal tract diseases. Terapevticheskii arkhiv. 2013; 85(4):102–105. (in Russ.)

2. Elli L., Norsa L., Zullo A., et al. Diagnosis of chronic anaemia in gastrointestinal disorders: A guideline by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) and the Italian Society of Paediatric Gastroenterology Hepatology and Nutrition (SIGENP). Dig Liver Dis. 2019 Apr;51(4):471–483. Doi: 10.1016/j.dld.2019.01.022

3. Mahadea D., Adamczewska E., Ratajczak A. E., et al. Iron Defi ciency Anemia in Infl ammatory Bowel Diseases- A Narrative Review. Nutrients. 2021 Nov 10;13(11):4008. doi: 10.3390/nu13114008

4. Stuklov N. I. Iron deficiency syndromes associated with diseases of the gastrointestinal tract: state-of-theart and new prospects for treatment. Кlin. Med. 2016; 94(6):410–418. (in Russ.) doi: 10.18821/0023–2149–2016–94–6–410–418

5. Verma S., Cherayil B. J. Iron and infl ammation – the gut reaction. Metallomics. 2017 Feb 22;9(2):101–111. doi: 10.1039/c6mt00282j

6. Bergamaschi G., Di Sabatino A., Corazza G. R. Pathogenesis, diagnosis and treatment of anaemia in immune- mediated gastrointestinal disorders. Br J Haematol. 2018 Aug;182(3):319–329. doi: 10.1111/bjh.15254

7. Chaparro C. M., Suchdev P. S. Anemia epidemiology, pathophysiology, and etiology in low- and middle- income countries. Ann N Y Acad Sci. 2019 Aug;1450(1):15–31. Doi: 10.1111/nyas.14092

8. Myint Z. W., Oo T. H., Thein K. Z., et al. Copper deficiency anemia: review article. Ann Hematol. 2018 Sep;97(9):1527–1534. doi: 10.1007/s00277–018–3407–5

9. Markova E. A., Khashukoeva A. Z., Khlynova S. A., et al. Anemia in elderly women. Rational prevention. Evidence base. Meditsinskiy sovet = Medical Council. 2021;(3):128–134. (In Russ.) doi: 10.21518/2079–701X-2021–3–128–134

10. Rybina O., Gubkin A., Sakhin V., Rukavitsyn O. Anemic Syndrome in Gastroenterological Diseases: Problems and Solutions. Hematology. Transfusiology. Eastern Europe. 2020;6(3):357–371. (in Russ.) doi: 10.34883/PI.2020.6.3.022

11. Mikhaĭlova E. A., Iadrikhinskaia V. N., Savchenko V. G. Aplasticheskie anemii i virusnye gepatity (postgepatitnye aplasticheskie anemii) [Aplastic anemia and viral hepatitis (posthepatitic aplastic anemia)]. Ter Arkh. 1999;71(7):64–9. Russian. PMID: 10481870.

12. Boltaev K. J., Mirzoeva M. R. Features of anemia in patients with chronic hepatitis virusnimi. Bulletin of the Bashkir State Medical University. 2019;(1):55–61. (in Russ.)

13. Ntanishyan K. I., Sabirov K. R., Shcherbakova O. V., et al. Autoimmune hemolytic anemia associated with mesenteric teratomaю. Terapevticheskii arkhiv. 2017;89(1):78–81. doi: 10.17116/terarkh201789178–81

14. Chaunzwa T. L., O’Shea J., Boggs N. A., et al. Hemolytic Anemia and Gastric Carcinoid in a Russian Seafarer: Highlighting the Role of Diagnostic Technologies in Modern Clinical Practice. Yale J Biol Med. 2018 Sep 21;91(3):243–246. PMID: 30258311; PMCID: PMC6153615.

15. Safi ri S., Kolahi A. A., Noori M., et al. Burden of anemia and its underlying causes in 204 countries and territories, 1990–2019: results from the Global Burden of Disease Study 2019. J Hematol Oncol. 2021 Nov 4;14(1):185. doi: 10.1186/s13045–021–01202–2

16. Marton I., Agocs S., Babik B. Az anaemiak epidemiologiaja [Epidemiology of anemia]. Orv Hetil. 2020 Sep;161(37):1569–1573. Hungarian. Doi: 10.1556/650.2020.31916

17. Vorobev S., Petrushin M., Ushakov D.1, Mikhralieva B. Fequency and role of anemia in patients in rescue units and intensive care. Sciences of Europe. 2021;(63–2(63):20–25. (in Russ.) doi: 10.24412/3162–2364–2021–63–2–20–25

18. Zjubina L. J., Shpagina L. A., Loseva M. I., et al. Clinicofunctional state of stomach and liver in condition of chronical sideropenia. Th e Bulletin of Siberian Branch of Russian Academy of Medical Sciences. 2009;29(3):56–63. (in Russ.)

19. Tettamanti M., Lucca U., Gandini F., et al. Prevalence, incidence and types of mild anemia in the elderly: the “Health and Anemia” population- based study. Haematologica. 2010 Nov;95(11):1849–56. doi: 10.3324/haematol.2010.023101

20. Shah Y., Patel D., Khan N. Iron deficiency anemia in IBD: an overlooked comorbidity. Expert Rev Gastroenterol Hepatol. 2021 Jul;15(7):771–781. Doi: 10.1080/17474124.2021.1900730

21. Drozdov V. N., Lishchinskaya A. A., Parfenov A. I., et al. Clinicopathogenetic variants of anemia in patients with intestinal infl ammation. Terapevticheskii arkhiv. 2012;84(2):36–41. (in Russ.)

22. Stein J., Connor S., Virgin G. Anemia and iron deficiency in gastrointestinal and liver conditions. World J Gastroenterol. 2016 Sep 21;22(35):7908–25. doi: 10.3748/wjg.v22.i35.7908

23. Alekseeva O. P. Modern principles in the diagnostics and treatment of iron defi ciency anemia and iron defi ciency in gastroenterological diseases: review of current clinical guidelines. Remedium. 2021;(2):70–76. (In Russ.) doi: 10.21518/1561–5936–2021–2–70–76

24. Hill A., Hill Q. A. Autoimmune hemolytic anemia. Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):382–389. doi: 10.1182/asheducation-2018.1.382

25. Butt N., Khan M. A., Abid Z., Haleem F. A Case of Polyautoimmunity: Celiac Hepatitis, Grave’s Disease and Autoimmune Hemolytic Anemia. J Coll Physicians Surg Pak. 2019 Dec;29(12): S106-S108. doi: 10.29271/jcpsp.2019.12.S106

26. Zhao D. T., Liu Y. M., Han Y., et al. Fluctuations of antimitochondrial antibodies and anti-gp210 antibody in a patient with primary biliary cholangitis and Sjogren syndrome with subsequent autoimmune hemolytic ane mia: A case report. Medicine (Baltimore). 2020;99(3): e18856. doi: 10.1097/MD.0000000000018856

27. Uddin S. M.M., Haq A., Haq Z., Yaqoob U. Case Report: Rare comorbidity of celiac disease and Evans syndrome: The rare correlation of Celiac and Evans syndrome. F1000Res. 2019 Feb 14;8:181. doi: 10.12688/f1000research.18182.1

28. Hariz A., Hamdi M. S., Boukhris I., Cherif E. Autoimmune haemolytic anaemia in pancreatic adenocarcinoma: a potential paraneoplastic presentation. BMJ Case Rep. 2019 Jul 15;12(7): e229807. doi: 10.1136/bcr-2019–229807

29. Agrawal K., Alfonso F. A Rare Association of Autoimmune Hemolytic Anemia with Gastric Adenocarcinoma. Case Rep Oncol Med. 2017;2017:8414602. doi: 10.1155/2017/8414602

30. Rybas A. V. Autoimmune hemolytic anemia: clinical lecture. Journal of young scientist. 2016;15(4):36–40. (in Russ.)

31. Kuzminova Z. A., Smetanina N. S. Autoimmune haemolytic anaemia: modern diagnosis and therapy. Pediatric Hematology/Oncology and Immunopathology. 2016;15(3):5–11. (In Russ.) doi:10.24287/1726–1708–2016–15–3–5–11

32. Tsvetaeva N.V., Lukina E. A. Nikulina O. F. Clinical practice guidelines for the diagnosis and occurrence of autoimmune hemolytic anemia (AIHA) in adults. Available at: https://npngo.ru/uploads/media_document/291/84cbcaeb-518f-4a7d-b081–88f7fbb016fc.pdf (Access: 05.05.2021)

33. Kalfa T. A. Warm antibody autoimmune hemolytic anemia. Hematology Am Soc Hematol Educ Progr. 2016; 2:690–697.

34. Meyer O., Stahl D., Beckhove P., et al. Pulsed high-dose dexamethasone in chronic autoimmunehaemolytic anaemia of warm type. Br J Haematol. 1997; 98:860–862.

35. Krasnovskiy A. L., Grigor’iev S.P., Alyokhina R. M., et al. Modern diagnostic and treatment of vitamin В12 defi ciency. Th e Clinician. 2016;10(3):15–25. (In Russ.) doi: 10.17650/1818–8338–2016–10–3–15–25

36. Carmel R. Subclinical cobalamin defi ciency. Curr Opin Gastroenterol. 2012 Mar;28(2):151–8. doi: 10.1097/MOG.0b013e3283505852

37. Toh B. H. Pathophysiology and laboratory diagnosis of pernicious anemia. Immunol Res. 2017 Feb;65(1):326–330. doi: 10.1007/s12026–016–8841–7

38. Levina A. A., Mesheryakova L. M., Tsibulskaia M. M., Sokolova T. V. Th e diff erential diagnostic of anemia. Klin Lab Diagn. 2015; 60 (12):26–30. (in Russ.)

39. Andreichev N. A. Th e diff erential diagnostic of anemia unrelated to iron metabolism. Rossiiskii meditsinskii zhurnal (Medical Journal of the Russian Federation, Russian journal). 2016;22(5):259–266 (In Russ.) doi: 10.18821/0869–2106–2016–22–5–259–266

40. Perekatova T. N., Ostroumova M. N. Eshche raz o deficite vitamina В 12[Once again about the defi ciency of vi ta min B12]. Clin. Oncohematology. 2009;2(2):185–195. (in Russ.)

41. Simonenko V. B., Gorobets V. N., Shalavin A. N., et al. A case of funicular myelosis combined with severe pernicious anemia. Clinical Medicine (Russian Journal). 2020;98(5):383–385. (In Russ.) doi:10.30629/0023–2149–2020–98–5–383–385

42. Koulidiati J., Sawadogo S., Sagna Y., et al. Maladie de Biermer: aspects diagnostiques et evolutifs au Burkina Faso [Pernicious anemia: diagnosis and course in Burkina Faso]. Med Sante Trop. 2015 Oct- Dec;25(4):428–31. French. doi: 10.1684/mst.2014.0417

43. Zyrina G. V., Vorob’ev S. A. Clinical and functional symptoms of funicular myelosis and chronic gastritis in patients with B12-defi ciency anemia. Clinical Medicine (Russian Journal). 2013;91(5):53–55. (in Russ.)

44. Embutnieks Yu.V., Voynovan I. N., Kolbasnikov S. V., Bordin D. S. Autoimmune gastritis: pathogenesis, modern approaches to diagnosis and treatment. Pharmateca. 2017;(S5):8–15. (in Russ.)

45. Neumann W., Coss E., Rugge M., et al. Autoimmune atrophic gastritis – pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol. 2012; 10, 529–541. doi: 10.1038/nrgastro.2013.101

46. Shchelochenkov S. V., Guskova O. N., Kolbasnikov S. V., Bordin D. S. Autoimmune Gastritis: Unresolved Diagnostic Issues, the Importance of Intraluminal Endoscopy. Eff ective pharmacotherapy. 2021;17(4):76–81. (in Russ.) doi: 10.33978/2307–3586–2021–17–4–76–8

47. Belkovets A. V., Ozhiganova N. V., Antipenko A. G., Kurilovich S. A. Autoimmune gastritis in clinical practice. Experimental and Clinical Gastroenterology. 2020;(10):142–147. (In Russ.) doi: 10.31146/1682–8658-ecg-182–10–142–147

48. Villanacci V., Casella G., Lanzarotto F., et al. Autoimmune gastritis: relationships with anemia and Helicobacter pylori status. Scand J Gastroenterol. 2017 Jun- Jul;52(6–7):674–677. Doi: 10.1080/00365521.2017.1288758

49. Hughes J. W., Muegge B. D., Tobin G. S., et al. High-risk gastric pathology and prevalent autoimmune diseases in patients with pernicious anemia. Endocr Pract. 2017 Nov;23(11):1297–1303. doi: 10.4158/EP-2017–0056

50. Shah S. C., Piazuelo M. B., Kuipers E. J., Li D. AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review. Gastro enterology. 2021 Oct;161(4):1325–1332.e7. Doi: 10.1053/j.gastro.2021.06.078

51. Marcoullis G., Parmentier Y., Nicolas J. P., et al. Cobalamin malabsorption due to nondegradation of R proteins in the human intestine. Inhibited cobalamin absorption in exocrine pancreatic dysfunction. J Clin Invest. 1980 Sep;66(3):430–40. doi: 10.1172/JCI109873

52. Martin- Masot R., Nestares M. T., Diaz- Castro J., et al. Multifactorial Etiology of Anemia in Celiac Disease and Effect of Gluten- Free Diet: A Comprehensive Review. Nutrients. 2019 Oct 23;11(11):2557. doi: 10.3390/nu11112557

53. Parfenov A. I. Hematologic disorders in celiac disease. Terapevticheskii arkhiv. 2011;83(7):68–73. (in Russ.)

54. Oreshko L. S., Bakulin I. G., Avalueva E. B. et al. Modern understanding of adult celiac disease. Experimental and Clinical Gastroenterology. 2021;(4):84–95. (In Russ.) doi: 10.31146/1682–8658-ecg-188–4–84–95

55. Madanchi M., Fagagnini S., Fournier N., et al. The Relevance of Vitamin and Iron Defi ciency in Patients with Inf lammatory Bowel Diseases in Patients of the Swiss IBD Cohort. Inflamm Bowel Dis. 2018 Jul 12;24(8):1768–1779. doi: 10.1093/ibd/izy054

56. Freedberg D. E., Kim L. S., Yang Y. X.. The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association. Gastroenterology. 2017 Mar;152(4):706–715. doi: 10.1053/j.gastro.2017.01.031

57. Vaezi M. F., Yang Y. X., Howden C. W. Complications of Proton Pump Inhibitor Th erapy. Gastroenterology. 2017 Jul;153(1):35–48. doi: 10.1053/j.gastro.2017.04.047

58. Ao M., Tsuji H., Shide K., et al. High prevalence of vitamin B-12 insuffi ciency in patients with Crohn’s disease. Asia Pac J Clin Nutr. 2017;26(6):1076–1081. doi: 10.6133/apjcn.022017.13

59. Langan R. C., Goodbred A. J. Vitamin B12 Defi ciency: Recognition and Management. Am Fam Physician. 2017 Sep 15;96(6):384–389. PMID: 28925645.

60. Gubonina I. V., Shchukina O. B., Stuklov N. I., et al. Anemia in infl ammatory bowel diseases: the approaches to its diagnosis, treatment and prevention. Almanac of Clinical Medicine. 2019;47(8):721–732. (in Russ.) doi: 10.18786/2072–0505–2019–47–078

61. Anderson G..J, Frazer D. M.. Current understanding of iron homeostasis. Am J Clin Nutr. 2017 Dec;106(Suppl 6):1559S-1566S. doi: 10.3945/ajcn.117.155804

62. Stein J., Hartmann F., Dignass A. Diagnosis and management of iron defi ciency anemia in patients with IBD. Nat Rev Gastroenterol Hepatol. 2010; 7:599–610. doi:10.1038/nrgastro.2010.151

63. Osipenko M. F., Zhuk E. A., Grishchenko N. G., et al. Iron defi ciency anemia in the practice of a gastroenterologist (according to AGA recommendations). Experimental and Clinical Gastroenterology. 2021;191(7):56–61. (In Russ.) doi: 10.31146/1682–8658-ecg-191–7–56–61

64. Trukhan D. I., Degovtsov E. N., Nikonenko V. A., Sa moilov D. V. Iron defi ciency anemia in the practice of a gastroenterologist and surgeon: current aspects of diagnostics and treatment. Consilium Medicum. 2020;22(8):71–77. (in Russ.) doi: 10.26442/20751753.2020.8.200357

65. Bengi G., Keyvan H., Durmaz S. B., Akpınar H. Frequency, types and treatment of anemia in turkish patients with inflammatory bowel disease. World J Gastroenterol. 2018;24(36):4186–4196. doi: 10.3748/wjg.v24.i36.4186

66. Voytsekhovskiy V. V., Khaustov A. F., Pivnik A. V., et al. Small intestinal tumors as a cause of chronic iron deficiency anemia. Terapevticheskii arkhiv. 2011;83(10):11–18. (in Russ.)

67. Zubrikhina G. N., Blindar V. N., Matveeva I. I. Diff erential diagnosis of anemia in true and functional iron defi ciency in patients with chronic diseases (malignant tumors). Terapevticheskii arkhiv. 2016; 88(4):61–67. (in Russ.)

68. Pietrangelo A., Trautwein C. Mechanisms of disease: The role of hepcidin in iron homeostasis – implications for hemochromatosis and other disorders. Nat Clin Pract Gastroenterol Hepatol. 2004 Nov;1(1):39–45. doi: 10.1038/ncpgasthep0019. PMID: 16265043.

69. Xu Y., Alfaro- Magallanes V.M., Babitt J. L. Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders. Br J Haematol. 2021 Jun;193(5):882–893. doi: 10.1111/bjh.17252

70. Gorokhovskaya G. N., Petina M. M. An old patient with iron deficient anemia in therapeutic practice. Terapevticheskii arkhiv. 2008;80(12):66–68. (in Russ.)

71. Akimovа A. V., Nevskaya A. V., Milashchenko A. I., Kondrashova E. V. Clinical Features of Anemia of Chronic Diseases in the Th erapeutic Hospital. Vestn. Ural. Med. Akad. Nauki. Journal of Ural Medical Academic Science. 2018;15 (1):5–11. (in Russ.) doi: 10.22138/2500–0918–2018–15–1–5–11

72. Th eurl I., Aigner E., Th eurl M., et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood. 2009 May 21;113(21):5277–86. doi: 10.1182/blood-2008–12–195651

73. Cheverie J. N., Lam J., Neki K., et al. Paraesophageal hernia repair: a curative consideration for chronic anemia? Surg Endosc. 2020 May;34(5):2243–2247. doi: 10.1007/s00464–019–07014–3

74. Akpinar H., Cetiner M., Keshav S., et al. Diagnosis and treatment of iron defi ciency anemia in patients with inflammatory bowel disease and gastrointestinal bleeding: iron defi ciency anemia working group consensus report. Turk J Gastroenterol. 2017 Mar;28(2):81–87. doi: 10.5152/tjg.2017.17593

75. Mahadev S., Laszkowska M., Sundstrom J., et al. Prevalence of Celiac Disease in Patients With Iron Defi ciency Anemia- A Systematic Review With Metaanalysis. Gastroenterology. 2018 Aug;155(2):374–382.e1. doi: 10.1053/j.gastro.2018.04.016

76. Filatov L. B., Berman V. B. Iron defi ciency anemia as a consequence of iron malabsorbtion in coeliac disease. Oncohematology. 2010;3(3):284–288. (in Russ.)

77. Mucke V., Mucke M. M., Raine T., Bettenworth D. Diagnosis and treatment of anemia in patients with inf lammatory bowel disease. Ann Gastroenterol. 2017;30(1):15–22. doi: 10.20524/aog.2016.0083

78. Tulewicz- Marti E., Moniuszko A., Rydzewska G. Management of anemia in inflammatory bowel disease: a challenge in everyday clinical practice. Prz Gastroenterol. 2017;12(4):239–243. doi: 10.5114/pg.2017.72096

79. Shulyat’Eva N.V., Drozdov V. N., Serebrova S. Yu., et al. The value of the Н. pylori infection in the development of iron defi ciency. Experimental and Clinical Gastroenterology. 2018;(6):105–110. (In Russ.)

80. Bergamaschi G., Markopoulos K., Albertini R., et al. Anemia of chronic disease and defective erythropoietin production in patients with celiac disease. Haematologica. 2008 Dec;93(12):1785–91. doi: 10.3324/haematol.13255

81. Montoro- Huguet M.A., Santolaria- Piedrafita S., Canamares- Orbis P., Garcia- Erce J. A. Iron Defi ciency in Celiac Disease: Prevalence, Health Impact, and Clinical Management. Nutrients. 2021 Sep 28;13(10):3437. doi: 10.3390/nu13103437

82. Manley J., Ibrahim Y., Ansell J., et al. Small bowel adenocarcinoma: Case reports and review of the literature. Arab J Gastroenterol. 2021 Sep;22(3):240–245. Doi: 10.1016/j.ajg.2021.07.003

83. Stuklov N. I., Basiladze I. G., Kovalchuk M. S., et al. New options in management of Iron- Defi ciency syndromes in Inflammatory Bowel Disease. Experimental and Clinical Gastroenterology. 2019;(2):143–150. (In Russ.) doi: 10.31146/1682–8658-ecg-162–2–143–150

84. Chistyakova A. V., Stuklov N. I. Diagnostics and choice of treatment tactics for iron defi ciency anemia in gastroenterological patients. RMJ. 2015;13:781–784. (in Russ.)

85. Dvoretsky L. I. Ferrous sulfate in the treatment of iron deficiency anemia: Th e positions continue. Terapevticheskii arkhiv. 2017;89(10):108–112. (in Russ.) doi: 10.17116/terarkh20178910108–112

86. Galmen K., Hojer J. Jarnintoxikation – forgift ning med laittillgangligt lakemedel [Iron intoxication – poisoning with easily accessible medicines]. Lakartidningen. 2014 Sep 17–23;111(38):1576–7. Swedish. PMID: 25606656.

87. Gumber M. R., Kute V. B., Shah P. R., et al. Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis. Ren Fail. 2013;35(5):729–31. doi: 10.3109/0886022X.2013.790299

88. Dhar A., Kabiru D., Johnson M., et al. PTH-15 Economic analysis of intravenous iron infusion in IBD and IDA: real world data from UK. Gut. 2021;70: A178. doi:10.1136/gutjnl-2021–325210

89. Auerbach M., Munoz M., Macdougall I. C. Intravenous iron: out of sight, out of mind. Lancet Haematol. 2018 Jan;5(1): e10-e12. doi: 10.1016/S2352–3026(17)30230–2

90. Auerbach M., Gafter- Gvili A., Macdougall I. C. Intravenous iron: a framework for changing the management of iron defi ciency. Lancet Haematol. 2020 Apr;7(4): e342-e350. doi: 10.1016/S2352–3026(19)30264–9

91. Snook J., Bhala N., Beales I. L.P., et al. British Society of Gastroenterology guidelines for the management of iron defi ciency anaemia in adults. Gut. 2021;70:2030–2051. doi: 10.1136/gutjnl-2021–325210

92. Kudykin M. N. Modern possibilities of correcting iron defi ciency anemia in patients with pathology of the digestive system. Consilium Medicum. 2017;19(7.2. Surgery):36–41. (in Russ.) doi: 10.26442/2075–1753_19.7.2.36–41

93. Schroder O., Mickisch O., Seidler U. et al Intravenous iron sucrose versus oral iron supplementation for the treatment of iron defi ciency anemia in patients with infl ammatory bowel disease – a randomized, controlled, open-label, multicenter study. Am J Gastroenterol. 2005 Nov;100(11):2503–9. doi: 10.1111/j.1572–0241.2005.00250.x

94. Mayev I. V., Dicheva D. T., Andreev D. N., Subbotina Yu. S. Difficulties in diagnosing iron deficiency anemia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014;24(3):98–103. (in Russ.)

95. Vorob'yev S.A., Zyabreva I. A. Neuroendocrine tumor (carcinoid) of the small intestine as the cause of recurrent iron-defi ciency anemia (clinical observation). Upper Volga Medical Journal. 2020;19(4):38–44. (in Russ.)


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Vorobyev S.A. Anemia and diseases of the gastrointestinal tract. Experimental and Clinical Gastroenterology. 2022;(4):20-32. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-200-4-20-32

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