Diagnostics of the Small Intestinal Bacterial Overgrowth Syndrome
R. G. Plavnik,
E. V. Tivanova,
V. I. Nevmerzhitskiy,
T. E. Plavnik,
L. I. Gubaydulina,
M. A. Kalashnikova,
A. O. Eletskaja,
E. V. Jastrebova,
T. A. Batyukhno https://doi.org/10.31146/1682-8658-ecg-196-12-15-20
Abstract
The Small Intestine Bacterial Overgrowth syndrome ( SIBO) is a widespread pathology both independently and in combination with other diseases of the gastrointestinal tract, therefore, its timely and accurate diagnosis remains a very urgent task.
Aim. Purpose of the study: comparative assessment of the diagnostic information content of two methods for diagnosing SIBO—hydrogen-methane breath test (HMBT) and stool analysis for short-chain fatty acids (SCFA).
Material and Methods: 65 patients aged from 18 to 76 years were examined. 40 made up the main group, with clinical symptoms of SIBO, and 25—the control group. All patients underwent HMBT with the «SIBRTEST» test kit and stool analysis for SCFA. For both tests, diagnostic sensitivity, specifi city, and accuracy were calculated and comparatively evaluated.
Results: HMBT showed sensitivity 90.24%, specifi city 95.83%, accuracy 92.3%. The analysis of feces for SCFA showed, respectively, a sensitivity of 90.24%, a specifi city of 50.0% and an accuracy of 75.38%.
Conclusion: HMBT with the SIBRTEST test kit can be recommended in the diagnosis of SIBO. The SCFA test should be treated with caution due to the high probability of false positive results.
About the Authors
R. G. Plavnik
«ISOCARB» LLC
Russian Federation
Russian Federation
Roman G. Plavnik, Candidate of Medical Sciences, Deputy General Director for Science and Implementation
Moscow
E. V. Tivanova
Central Research Institute of Epidemiology, Rospotrebnadzor
Russian Federation
Russian Federation
Elena V. Tivanova, Head of Laboratory Medicine
Moscow
V. I. Nevmerzhitskiy
Moscow Institute of Physics and Technology
Russian Federation
Russian Federation
Vasiliy I. Nevmerzhitskiy, Ph.D., Associate Professor of the Department of Applied Physics
SPIN: 6854–8596
Moscow
T. E. Plavnik
City Polyclinic195 of the Moscow Department of Health
Russian Federation
Russian Federation
Tatiana E. Plavnik, gastroenterologist
Moscow
L. I. Gubaydulina
Clinical Hospital 85 FMBA of Russia
Russian Federation
Russian Federation
Landish I. Gubaydulina, Candidate of Medical Sciences, gastroenterologist
Moscow
M. A. Kalashnikova
Joint Hospital and Polyclinic of the Offi ce of the President of the Russian Federation
Russian Federation
Russian Federation
Marina A. Kalashnikova, gastroenterologist
Moscow
A. O. Eletskaja
CDC “Arbatsky” NMSC named after N. I. Pirogov
Russian Federation
Russian Federation
Anna O. Eletskaja, gastroenterologist
Moscow
E. V. Jastrebova
«BEST CLINIC» LLC
Russian Federation
Russian Federation
Elena V. Jastrebova, doctor—allergist- immunologist
Moscow
T. A. Batyukhno
OKDC PJSC “Gazprom”
Russian Federation
Russian Federation
Tatiana A. Batyukhno, Candidate of Medical Sciences, gastroenterologist
Moscow
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Review
For citations:
Plavnik R.G., Tivanova E.V., Nevmerzhitskiy V.I., Plavnik T.E., Gubaydulina L.I., Kalashnikova M.A., Eletskaja A.O., Jastrebova E.V., Batyukhno T.A. Diagnostics of the Small Intestinal Bacterial Overgrowth Syndrome. Experimental and Clinical Gastroenterology. 2021;(12):15-20. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-196-12-15-20
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