Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure
https://doi.org/10.31146/1682-8658-ecg-191-7-43-47
Abstract
This study aims to evaluate the level of plasma homocysteine in patients with acute post-resection hepatic failure, depending on the degree of the disease. Materials and Methods. The article presents the results of a study of plasma homocysteine levels in 40 patients with c different classes of acute post-resection liver failure. Indications for liver resection were: primary liver cancer 11 (27%), metastatic liver lesions 21 (53%), parasitic liver diseases 3 (7%), benign liver formations 5 (13%). Patients were divided into 3 groups - Patients with Post hepatectomy liver failure (PHLF) class developed in the postoperative period A, B and C. Results. Analysis of the data showed that the initially normal level of plasma homocysteine before liver resection (surgical treatment) and after has different developmental options. Depending on the class of post-resection hepatic failure, the level of plasma homocysteine changes and has deviations from the reference values. In a comparative analysis of the average homocysteine values in the group of patients with post-resection hepatic insufficiency of class A, after surgical treatment, they were significantly lower than in patients with PHLF B and C. In particular, in patients with class B and C PNF, there is a significant trend towards an increase in homocysteine levels after surgery. Hyperhomocysteinemia may be a risk factor for the development of acute liver failure after surgical treatment for focal liver disease. Possibly, its adverse effect on the function and restoration of the liver parenchyma, which requires further targeted study.
About the Authors
S. S. Dunaevskaya
FSBEF HE Krasnoyarsk State Medical University named after prof. V. F. Voyno- Jaseneckiy Ministry of Health RF
Russian Federation
Russian Federation
A. A. Kosik
FSBEF HE Krasnoyarsk State Medical University named after prof. V. F. Voyno- Jaseneckiy Ministry of Health RF
Russian Federation
Russian Federation
A. N. Narkevich
FSBEF HE Krasnoyarsk State Medical University named after prof. V. F. Voyno- Jaseneckiy Ministry of Health RF
Russian Federation
Russian Federation
References
1. Vishnevsky V. A., Kovalenko Yu.A., Andreytseva O. I., Ikramov R. Z., Efanov M. G., Nazarenko N. A., Tupikin K. A. Post-resection hepatic failure: current problems of definition, epidemiology, pathogenesis, assessment of risk factors, prevention and treatment. Ukrainian Journal of Surgery. 2013; 22 (3): 172-182.@@ Вишневский В. А., Коваленко Ю. А., Андрейцева О. И., Икрамов Р. З., Ефанов М. Г., Назаренко Н. А., Тупикин К. А. Пострезекционная печеночная недостаточность: современные проблемы определения, эпидемиологии, патогенеза, оценки факторов риска, профилактики и лечения. Украинский журнал хирургии. 2013; 22(3): 172-182.
2. Lukashik S. P., Karpov I. A. Acute liver failure in adults. Clinical Microbiology and Antimicrobial Chemotherapy. 2019: 21(1)46-55. Doi: 10.36488/cmac.2019.1.46-55@@ Лукашик С. П., Карпов И. А. Острая печеночная недостаточность у взрослых. Клиническая микробиология и антимикробная химиотерапия. 2019; Т. 21. № 1: 46-55.
3. Kozyrin I. A., Ermakov N. A., Lyadov V. K., Kovalenko Z. A. Experience of two-stage liver resection (ALPPS). Surgery. 2014; 12: 24-28.@@ Козырин И. А., Ермаков Н. А., Лядов В. К., Коваленко З. А. Опыт двухэтапной резекции печени (ALPPS). Хирургия. 2014; 12: 24-28.
4. Lafaro K. J., Stewart C., Fong A., Fong Y. Robotic Liver Resection. Surg Clin North Am. 2020; 100(2): 265-281. doi: 10.1016/j.suc.2019.11.003
5. Krotova O. A., Granov D. A., Rutkin I. O. Syndrome of “insufficient liver size” after resection and transplantation of a liver fragment. Bulletin of Surgery named after I. I. Grekov. 2012; T.171.No. 3: 113-116.@@ Кротова О. А., Гранов Д. А., Руткин И. О. Синдром “недостаточного размера печени” после резекции и трансплантации фрагмента печени. Вестник хирургии им. И. И. Грекова.2012; Т. 171.№ 3: 113-116.
6. Shevchenko O. P., Dolgov V. V., Gichkun O. E., Kuntsevich N. V., Tsirulnikova O. M., Got’e S. V. Homocysteine in liver transplantation in young children. Bulletin of Transplantology and Artificial Organs. 2012; Т. 14.№ 4: 44-47.@@ Шевченко О. П., Долгов В. В., Гичкун О. Е., Кунцевич Н. В., Цирульникова О. М., Готье С. В. Гомоцистеин при трансплантации печени детям раннего возраста. Вестник трансплантологии и искусственных органов. 2012; Т. 14.№ 4: 44-47.
7. Liu P., Huang J., Zhong L. Role and mechanism of homocysteine in affecting hepatic protein-tyrosine phosphatase 1B. Biochim Biophys Acta Gen Subj. 2019; 1863(5): 941-949. doi:10.1016/j.bbagen.2019.03.007
8. Zhuravlyova L. V., Ogneva O. V., Vlasenko A. V. The role of resistin and homocysteine in the progression of functional liver disorders in patients with non-alcoholic fatty liver disease. Experimental and Clinical Gastroenterology. 2019;(8):11-15. (In Russ.) doi: 10.31146/1682-8658-ecg-168-8-11-15@@ Журавлева Л. В., Огнева Е. В., Власенко А. В. Роль резистина и гомоцистеина в прогрессировании функциональных нарушений печени у больных с неалкогольной жировой болезнью печени. Экспериментальная и клиническая гастроэнтерология. 2019; 8 (168): 11-15.
9. Fowler B. Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med. 2005; 5(2): 77-86. doi: 10.1055/s-2005-872394
10. Koller A., Szenasi A., Dornyei G., Kovacs N., Lelbach A., Kovacs I. Coronary Microvascular and Cardiac Dysfunction Due to Homocysteine Pathometabolism; A Complex Therapeutic Design. Curr Pharm Des. 2018; 24(25): 2911-2920. doi: 10.2174 / 1381612824666180625125450
11. Grek A, Arasi L. Acute Liver Failure. AACN Adv Crit Care. 2016; 27(4): 420-429. doi: 10.4037/aacnacc2016324
12. Rahbari N. N., Garden O. J., Padbury R., et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011; 149(5): 713-24. doi:10.1016/j.surg.2010.10.001
Review
For citations:
Dunaevskaya S.S., Kosik A.A., Narkevich A.N. Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure. Experimental and Clinical Gastroenterology. 2021;(7):43-47. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-191-7-43-47
Views:
375
Email this article 