Parkinson’s disease — the association of non-motor signs with gastrointestinal disorders and serum galanin levels
https://doi.org/10.31146/1682-8658-ecg-180-8-78-82
Abstract
Purpose of the study. The study of gastrointestinal disorders in patients with Parkinson’s disease (PD), an assessment of their relationship with other clinical manifestations and serum galanin levels.
Materials and methods. A comprehensive examination of 70 patients with PD and 17 people from the control group was conducted. A neurological examination was used in the work, testing using the following scales was used: a questionnaire for identifying autonomic disorders in patients with PD, cognitive questionnaires MMSE and MoCA, a Beck scale for detecting depression, a questionnaire for quality of life SF-36. Serum galanin level was determined by ELISA.
Results. Among non-motor manifestations in PD, gastrointestinal disturbances, mild cognitive impairment, and mild depression are dominant, which significantly reduces the quality of patient’s life. Correlation analysis revealed an association of the severity of gastrointestinal disturbances with the level of depression, cognitive decline, quality of life, and other autonomic manifestations. Serum galanine content in PD patients was lower than in healthy volunteers. The degree of decrease in humoral galanin in patients with PD is associated with the severity of gastrointestinal disorders.
Conclusion. Gastrointestinal disorders are observed in most patients with PD and are associated with other autonomic disorders, cognitive impairment, depression, which aff ects the quality of patients life. A reduced amount of galanin contributes to the formation of gastrointestinal disorders in PD and can be used for their objective diagnosis.
About the Authors
N. V. Selyanina
Perm State Medical University named after Academician E.A. Wagner (PSMU)
Russian Federation
Russian Federation
Nataliya V. Selyanina - Professor of the Department of Neurology and Medical Genetics, Doctor of Medical Sciences, Perm State Medical University named after Academician E. A. Wagner.
614000, Perm, st. Petropavlovskaya, 26
Yu. V. Karakulova
Perm State Medical University named after Academician E.A. Wagner (PSMU)
Russian Federation
Russian Federation
Yuliya V. Karakulova - Head of the neurology and medical genetics department, Professor, Doctor of medical sciences, Perm State Medical University named after Academician E.A. Wagner.
614000, Perm, st. Petropavlovskaya, 26
O. V. Khegai
Perm State Medical University named after Academician E.A. Wagner (PSMU)
Russian Federation
Russian Federation
Olga V. Khegai - Postgraduate student of the Department of Neurology and Medical Genetics Perm State Medical University named after Academician E. A. Wagner.
614000, Perm, st. Petropavlovskaya, 26
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Review
For citations:
Selyanina N.V., Karakulova Yu.V., Khegai O.V. Parkinson’s disease — the association of non-motor signs with gastrointestinal disorders and serum galanin levels. Experimental and Clinical Gastroenterology. 2020;(8):78-82. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-180-8-78-82
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