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Экспериментальная и клиническая гастроэнтерология

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Взаимосвязь муколитической бактерии Akkermansia muciniphila с колоректальным раком

https://doi.org/10.31146/1682-8658-ecg-178-6-158-165

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Аннотация

Колоректальный рак—заболевание, занимающее далеко не самое последнее место в статистике заболеваемости в Российской Федерации и в мире. Наряду с широко известными факторами риска развития данной патологии отмечается возможное участие в этом процессе некоторых представителей кишечной микробиоты. Так, в некоторых исследованиях предполагается, что с развитием колоректального рака взаимосвязана бактерия, способная расщеплять муцины,—Akkermansia muciniphila, однако другие работы подвергают это утверждение сомнению. В настоящем обзоре мы описываем ряд исследований, посвящённых определению зависимости наличия колоректального рака от количества A. muciniphila, взаимосвязи этой бактерии с развитием воспаления как предиктора онкогенеза, влиянию других представителей кишечной микробиоты на её функции, а также описываем один из возможных механизмов, связывающих способность этой бактерии расщеплять муцины с развитием онкогенеза.

Об авторах

А. М. Карамзин
ФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)
Россия

к. б. н., доцент кафедры микробиологии, вирусологии и иммунологии Института общественного здоровья имени Ф. Ф. Эрисмана,

Москва



А. В. Ропот
ФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)
Россия

студент 6 курса Международной школы «Медицина будущего»,

Москва



Р. Е. Бошьян
ФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)
Россия

к. м. н., доцент кафедры микробиологии, вирусологии и иммунологии Института общественного здоровья имени Ф. Ф. Эрисмана,

Москва



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Для цитирования:


Карамзин А.М., Ропот А.В., Бошьян Р.Е. Взаимосвязь муколитической бактерии Akkermansia muciniphila с колоректальным раком. Экспериментальная и клиническая гастроэнтерология. 2020;(6):158-165. https://doi.org/10.31146/1682-8658-ecg-178-6-158-165

For citation:


Karamzin A.M., Ropot A.V., Boshian R.E. Relationship of the mucin-degrading bacterium Akkermansia muciniphila with colorectal cancer. Experimental and Clinical Gastroenterology. 2020;(6):158-165. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-178-6-158-165

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ISSN 1682-8658 (Print)