Biological markers of Barrett’s esophagus progression to adenocarcinoma

T. A. Karmakova; S. S. Pirogov; A. D. Kaprin

doi:10.31146/1682-8658-ecg-177-5-91-98

Biological markers of Barrett’s esophagus progression to adenocarcinoma

T. A. Karmakova, S. S. Pirogov, A. D. Kaprin

https://doi.org/10.31146/1682-8658-ecg-177-5-91-98

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Abstract

Barrett’s esophagus (BE) is a condition in which a stratifi ed squamous epithelium of the distal esophagus is replaced with a metaplastic intestinal-type columnar epithelium. BE is a precancerous condition associated with an increased risk of esophageal adenocarcinoma (EA). Current clinical practice guidelines recommend endoscopic surveillance with histological examination of esophageal biopsies for early detection of the EA. Epithelial dysplasia is the only clinically meaningful indicator of the risk for development carcinoma in BE, which is now used in practice. The existing limitations of this approach require new tools for the detection of early neoplastic disorders in BE and additional criteria to assess a risk for their progression. Within the framework of this review, the most signifi cant genetic and molecular indicators that can claim the role of diagnostic or predictive biological markers in BE are considered.

Keywords

Barrett’s esophagus, esophageal adenocarcinoma, biological markers

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For citations:

Karmakova T.A., Pirogov S.S., Kaprin A.D. Biological markers of Barrett’s esophagus progression to adenocarcinoma. Experimental and Clinical Gastroenterology. 2020;174(5):91-98. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-177-5-91-98

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Experimental and Clinical Gastroenterology

Biological markers of Barrett’s esophagus progression to adenocarcinoma

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

User

Experimental and Clinical Gastroenterology

Biological markers of Barrett’s esophagus progression to adenocarcinoma

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

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