The role of liver in modifi cation of peptidergic mechanisms of regulation of digestive glands
https://doi.org/10.31146/1682-8658-ecg-176-4-128-132
Abstract
Studies were performed on 84 rats in 12 series, 7 acute experiments in each series. Studied the change in gastric and pancreatic secretion with the introduction of the short-chain peptide CCK-8 and pentagastrin in the presence of trypsin and contrуcal. It was concluded that the short-chain peptide CCK-8 and pentagastrin are utilized by the liver to a large extent. Trypsin, when passing through the liver, reduces the ability of the liver to utilize CCK-8 and pentagastrin. The protease inhibitor contrуkal® when passing through the liver increases the ability of the liver to utilize these peptides. It is concluded that the liver is involved in the modifi cation of peptidergic mechanisms of regulation of the digestive glands.
Keywords
liver,
utilization,
CCK-8,
pentagastrin,
trypsin,
contrycal®,
rats,
gastric secretion,
pancreas secretion
About the Authors
M. A. Zhuraeva
Andijan State Medical Institute
Uzbekistan
Uzbekistan
Candidate of Medical Sciences, Associate Professor of the Department of General Practitioners 1,, Faculty of Medicine, applicant
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
V. A. Aleinik
Andijan State Medical Institute
Uzbekistan
Doctor of Medical Sciences, Professor, professor, professor of the Department of Normal Physiology
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
Uzbekistan
Doctor of Medical Sciences, Professor, professor, professor of the Department of Normal Physiology
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
S. M. Babich
Andijan State Medical Institute
Uzbekistan
Uzbekistan
Candidate of Medical Sciences, Associate Professor, Head of the Department of Social Hygiene and Health Management
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
M. K. Yakubbekova
Andijan State Medical Institute
Uzbekistan
Assistant of the Department of Faculty Therapy, Faculty of Medicine
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
Uzbekistan
Assistant of the Department of Faculty Therapy, Faculty of Medicine
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
N. A. Yusupova
Andijan State Medical Institute
Uzbekistan
Applicant, Assistant of the Department of Faculty Therapy
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
Uzbekistan
Applicant, Assistant of the Department of Faculty Therapy
Republic of Uzbekistan, Andizhan, 170127, Atabekova St., 1
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Review
For citations:
Zhuraeva M.A., Aleinik V.A., Babich S.M., Yakubbekova M.K., Yusupova N.A. The role of liver in modifi cation of peptidergic mechanisms of regulation of digestive glands. Experimental and Clinical Gastroenterology. 2020;174(4):128-132. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-176-4-128-132
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