Update of Clinical Practice Guidelines for Clostridium difficile Infection by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): A Brief Overview of Key Points, Criticisms and Future Trends
Abstract
Clostridium difficile (Clostridioides difficile) infection is an important public health issue due to its high incidence, high risks of recurrences, attendant severe complications and death, as well as long length of hospital stay. In 2017, the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA) updated 2010 clinical practice guidelines for C. difficile infection. The article provides a brief overview of the updated IDSA/SHEA guidelines (2017). A critical look at these updated guidelines, considering some Russian and international recommendations, provides insights into effective strategies for treatment and prevention of C. difficile infection. Some promising strategies for primary prevention, treatment and prevention of C. difficile-associated disease recurrence with probiotics, human monoclonal antibodies against C. difficile toxin B (bezlotoxumab), intravenous immunoglobulin (IVIG) and vaccines, based on detoxified or recombinant forms of toxins, are highlighted in the article.
Keywords
Clostridioides difficile,
Clostridium difficile,
антибиотик-ассоциированная диарея,
псевдомембранозный колит,
пробиотики,
трансплантация фекальной микробиоты,
Clostridioides difficile,
Clostridium difficile,
antibiotic-associated diarrhea,
fecal microbiota transplantation,
probiotics,
pseudomembranous colitis
About the Authors
E. V. Skazyvaeva
North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of the Russia
Russian Federation
Russian Federation
M. I. Skalinskaya
North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of the Russia
Russian Federation
Russian Federation
I. G. Bakulin
North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of the Russia
Russian Federation
Russian Federation
M. S. Zhuravleva
North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of the Russia
Russian Federation
Russian Federation
E. V. Demyanova
State Research Institute of Highly Pure Biopreparations of FMBA of Russia
Russian Federation
Russian Federation
S. I. Sitkin
North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of the Russia; State Research Institute of Highly Pure Biopreparations of FMBA of Russia; Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre
Russian Federation
Russian Federation
Review
For citations:
Skazyvaeva E.V., Skalinskaya M.I., Bakulin I.G., Zhuravleva M.S., Demyanova E.V., Sitkin S.I. Update of Clinical Practice Guidelines for Clostridium difficile Infection by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): A Brief Overview of Key Points, Criticisms and Future Trends. Experimental and Clinical Gastroenterology. 2019;(5):3-14. (In Russ.)
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