Abstract
Purpose. To analysis of Russian and foreign literature about epidemiology, etiology and pathogenesis of chronic viral hepatitis B and C, including the factors that are likely to have effect on the progression of liver fibrosis, such as, condition of protein metabolism. Materials and methods. The literature data about this subject in the volume 58 sources of literature, 22 - Russian works and foreign - 36 was studied. Results and discussion. The most frequent factors that are likely to have effect on the progression of liver fibrosis, such as, etiology of chronic viral hepatitis B and C, combined viral pathology, features of the macrooganism, duration of infection, effect of alcohol and smoking were detected. The questions of the condition protein metabolism of chronic viral hepatitis B and C has been considered. Conclusion. The obtained data is different, because impact of the condition protein metabolism and other factors are important for learning and use in clinical practice with this pathology.