Protective effect of the new compound - salicyl-carnosine - on the formation of chronic acetate gastric ulcer in rats

Antiplatelet drugs are widely used for the prevention and treatment of vascular diseases of the heart and brain. The most popular drugs are non-steroidal anti-inflammatory drugs, the first place among which still belongs to acetylsalicylic acid (aspirin) and its derivatives. However, along with high clinical efficacy according to target parameters, these drugs have side effects that lead to damage to the mucous membrane of the gastrointestinal tract (GI). In order to eliminate the effects of damage to the gastrointestinal tract with the use of antiplatelet drugs, based on salicylic acid, using a natural dipeptide carnosine, a new compound was synthesized - salicyl-carnosine, which has an antiplatelet effect. A comparative study on carnosine, acetylsalicylic acid and salicyl-carnosine for the healing of ulcerative defect was carried out on the model of acetate gastric ulcer by Okabe. It was shown that salicyl-carnosine was more effective than carnosine both at the stage of ulcer formation (1-5 s) and at the stage of healing (5-10 s). Acetylsalicylic acid in the used model of gastric ulcer not only did not prevent the development of gastric ulcer, but also complicated the healing processes. The results indicate the possible prospects for the use of salicyl-carnosine as an antiplatelet drug in vascular pathologies (cardiac, Central nervous system, etc.), to avoid side effects associated with damage to the gastrointestinal tract, inherent in aspirin and other NSAIDs. Non-steroidal anti-inflammatory drugs

антиагреганты, аспирин, язвенные поражения ЖКТ, антиоксиданты, карнозин, крысы, antiplatelet agents, aspirin, gastrointestinal ulcer, antioxidants, carnosine, rats