Studies of the morphology, phase and elemental composition of gall stones by instrumental methods

V. E. Asadchikov; A. V. Buzmakov; A. E. Voloshin; I. G. Dyachkova; O. M. Zhigalina; V. G. Basu; D. N. Khmelenin; D. A. Zolotov; A. G. Ivanova; Yu. S. Krivonosov; V. V. Pantyushov; R. G. Saifutdinov

Studies of the morphology, phase and elemental composition of gall stones by instrumental methods

V. E. Asadchikov, A. V. Buzmakov, A. E. Voloshin, I. G. Dyachkova, O. M. Zhigalina, V. G. Basu, D. N. Khmelenin, D. A. Zolotov, A. G. Ivanova, Yu. S. Krivonosov, V. V. Pantyushov, R. G. Saifutdinov

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Abstract

The aim. The study of morphology and composition of gallbladder stones in the search for the possibility of differentiation of cholesterol type stones by X-ray tomography technique. Materials and methods. In-vitro investigation of gallstones were performed by the X-ray microtomography, X-ray phase analysis and electron microscopy methods. Results. The phase and element composition of gallstones were determined in our experiments. Cholesterol monohydrate, cholesterol anhydrous and calcium carbonate were discovered in the gallstones composition. 3D-distributions of linear attenuation coefficients of gallstones were obtained from X-ray microtomography measurements. The agreement of experimentally measured linear attenuation coefficients with the calculation based on tabular data for pure cholesterol is demonstrated. The cavities of different morphological structure formed in the process of growth were found in the gallstones. On the basis of X-ray, electron microscopic and optical measurements the possibility of formation of thin layers of bilirubin on the surface of cholesterol stones is demonstrated.