Feature of composition of fatty acids of erythrocyte membranes in patients with colorectal cancer of different stages

With the aim of highly sensitive chromatography- mass spectrometry (Agilent 7000B, USA) with triple quadrupole analyzer and electron ionization source). Followed by statistical processing of measurement results the fatty acid composition of erythrocyte membranes in patients with colorectal cancer (63,2+9,4 years; 57 men, 43 women) of different stages and localizations and persons of comparison group (61,7+7,5 years; 14 men, 10 women) was studied. The study revealed significant differences in fatty acid (FA) levels in erythrocyte membrane phospholipids in patients with colorectal cancer associated with the stage of disease and in control group. Patients with colorectal cancer (CRC) compared to the control group was set to increase level of polyunsaturated fatty acids, mainly due to the omega-3 (including docosapentaenoic, docosahexaenoic), since the early stages of CRC (p<0.001-0.05) and a decrease in the level of saturated C14:0, C15:0, C17:0 (p<0.01 to 0.02), monounsaturated (C16:1;7, C16:1;9, C18:1; t9 p<0,001-0,04) fatty acids, and the ratio of omega-6/omega-3 polyunsaturated fatty acids (p<0.001), correlating with the stage of CRC. The detected shifts indicate a change in the metabolism of fatty acids in the process of carcinogenesis. The peculiarities of the differences in the fatty acid composition of erythrocyte membranes in patients with CRR of different stages make it possible to conclude that they can be used in the diagnosis of the disease with an emphasis on the early stages of the disease. On the basis of the obtained results it is shown that further studies of individual fractions of LC and their role in the progression of the disease are necessary.

мембраны эритроцитов, жирные кислоты, колоректальный рак, хромато-масс-спектрометрия, erythrocyte membranes, fatty acids, colorectal cancer, chromatography-mass spectrometry