Preparations of standardized silymarin. Mechanisms of action and prospects for clinical application

Abstract

Standardized original silymarin has a number of therapeutic effects: membrane stabilizing; antioxidant; metabolic; antiinflammatory; detoxification; regenerative; antifibrotic; cytoprotective; reducing the severity of fatty liver disease; reduction of neutral fat in the liver; antiviral; immunomodulating; antifibrotic; antiproliferative; normalizing the level of cholesterol in the blood; antidepressant; diaphoretic; diuretic. The review provides data on clinical observations that testify to the efficacy and safety of standardized silymarin in order to recommend its use for the prevention and treatment of a number of diseases of the hepatobiliary system. The hepatoprotector Legalon (MEDA, Germany) has a high degree of purification according to Rottapharm | Madaus and meets the European standard for the content of silymarin in the preparation and is produced in accordance with GMP criteria. “Legalon” is a preparation, the quantitative determination of silymarin in which is carried out by a modern method of high-performance liquid chromatography. These factors allow us to treat Legalon as a “reference” preparation of silymarin.