Clinico-epidemiological characteristic of astrovirus infection in hospitalized adults in Novosibirsk

D. V. Kapustin; E. I. Krasnova; E. V. Zhirakovskaia; N. I. Khokhlova; S. N. Sokolov; N. V. Tikunova; I. V. Kuimova; A. N. Evstropov; V. G. Kuznetsova; L. M. Panasenko; I. Ya. Izvekova

Clinico-epidemiological characteristic of astrovirus infection in hospitalized adults in Novosibirsk

D. V. Kapustin, E. I. Krasnova, E. V. Zhirakovskaia, N. I. Khokhlova, S. N. Sokolov, N. V. Tikunova, I. V. Kuimova, A. N. Evstropov, V. G. Kuznetsova, L. M. Panasenko, I. Ya. Izvekova

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Abstract

Objectives of the study: determination of clinical and epidemiological features of astrovirus infection in adult residents of Novosibirsk hospitalized with acute gastroenteritis (AGE), and genetic characteristics of the identified isolates of astrovirus. Materials and methods: 1469 patients aged 15 to 91 years, hospitalized with a diagnosis of AGE in the period from January 2016 to February 2018 were examined. Along with the generally accepted methods of diagnosis, feces were examined by PCR for the presence of astroviruses, rotaviruses o and noroviruses of the second genogroup. Results: Viral etiology of AGE was established in 311(21.2%) people. Astrovirus infection was diagnosed in 27 (1.8%), inferior in frequency to noroviruses (13.5%) and rotaviruses (5.7%). Astroviruses were detected throughout the year, mostly in patients under the age of 30 (88.9%). Half of the cases of astrovirus AGE (48.1%) showed consumption of seafood on the eve disease. Astrovirus AGE proceeded in a moderate form, characterized by fever from the first day of the disease, in most patients with subfebrile (92.6%). In 81.4% of patients, watery diarrhea was observed, in the remaining 18.6% of patients the disease proceeded in the form of acute gastritis. Significant differences of clinical symptoms, indicators of a haemogram and coprogram in patients with astroviruses AGE from other viral OGE are not installed. Astroviruses of three genotypes, HAstV-4 (48%), HAstV-1 (44.5%) and HAstV-8 (7.5%) were circulating during the observation period. In 2016, HAstV-4 was dominant, and then HAstV-1 became dominant by the end of 2017. In two patients for the first time in Novosibirsk, HAstV-8 was determined. Conclusion: The absence of specific manifestations of viral AGE of various etiologies, including astrovirus AGE, determines the need to introduce into clinical practice test systems for the verification viral pathogens into clinical practice. The study of the genetic diversity of astroviruses reveals the change of the dominant genotype and is important for understanding the patterns of astrovirus circulation both in the Novosibirsk region and in Russia as a whole.

Keywords

острый гастроэнтерит, астровирусы, норовирусы, ротавирусы, клиническая и эпидемиологическая характеристика, полимеразная цепная реакция, генотипирование, acute gastroenteritis, astroviruses, noroviruses, rotaviruses, clinical and epidemiological characteristics, polymerase chain reaction, genotyping

About the Authors

D. V. Kapustin

Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” of the Ministry of Health of Russia (FSBEI HE NSMU MOH Russia); City Infectious Clinical Hospital No.1
Russian Federation

E. I. Krasnova

E. V. Zhirakovskaia

Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation

N. I. Khokhlova

S. N. Sokolov

Institute of Chemical Biology and Fundamental Medicine of the SB RAS; State Research Center of Virology and Biotechnology Vector
Russian Federation

N. V. Tikunova

Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation

I. V. Kuimova