Factors, associated with nonalcoholic steatohepatosis in patients with inflammatory bowel diseases

Purpose. To identify the factors associated with nonalcoholic steatohepatosis/steatohepatitis in patients with ulcerative colitis (UC) and Crohn’s disease (CD). Materials and methods. The study involved 47 patients diagnosed with ulcerative colitis (UC) or Crohn’s disease (CD) aged 24 to 64 years. The diagnosis of steatohepatosis/steatohepatitis was estimated according to the data of ultrasound diagnostic of liver. The study did not include alcohol abusers, as well as patients with viral and autoimmune hepatitis. Results. Patients with CD had a reliable association between platelet count and the presence of nonalcoholic steatohepatosis/steatohepatitis (median platelet count 287×10⁹/L, [192×10⁹/L; 420×10⁹/L] in patients with nonalcoholic steatohepatosis/steatohepatitis and 250×10⁹/L, [180×10⁹/L; 379×10⁹/L] in patients without nonalcoholic steatohepatosis/steatohepatitis, p = 0.01). There were no significant differences in the body mass index (BMI) and age between the groups with nonalcoholic steatohepatosis/steatohepatitis and without nonalcoholic steatohepatosis/steatohepatitis among the patients with CD. Between patients in the UC group with and without nonalcoholic steatohepatosis/steatohepatitis, significant differences were found in the BMI (median BMI 28,7 kg/m² [26,2 kg/m2; 32,7 kg/m²] and 20,9 kg/m² [18,4 kg/m²; 22,7 kg/m²], respectively, p=0.03), mean hospitalization rates (1,53 hospitalizations/year, [0,1 hospitalizations/year; 2,92 hospitalizations/year] and 0,83 hospitalizations/year, [0,36 hospitalizations/year; 1,46 hospitalizations/year] respectively, p=0,025) and age (median age 55,3 years [48 years; 62 years], and 30.4 years, [25 years; 35 years], respectively, р = 0,001). Conclusion. In patients with a CD factor associated with nonalcoholic steatohepatosis/steatohepatitis is the platelet count. In the case of the UC, steatohepatosis is associated with a high rate of hospitalization, BMI, and age.

Воспалительные заболевания кишечника, стеатогепатоз, индекс массы тела, тромбоциты, Inflammatory bowel diseases, steatohepatosis, body mass index, platelets