The cytokine and porphyrine spectrums in patients with non-alcoholic fatty lever disease

Purpose of the study. The study of the cytokine spectrum of blood serum and its relationship with the index of porphyrin metabolism. Materials and methods. 84 patients (22 women and 62 men) aged from 26 to 69 years (mean age 49.6 ± 1.3 years) were examined. The cytokine spectrum of TNF-α, IL-1β, IL-1Ra, IL-6, IL-8, IL-10 and excretory porphyrins: δ-aminolevulinic acid, porphobilinogen, uroporphyrin, and coproporphyrin were determined by special methods. Results. In 59 people (70.2%), elevated concentrations of cytokines in the serum were recorded. The deviations from the control values for IL-1Ra (39 people, 66.1%) and IL-6 (45 persons, 76.3%) were recorded more often. Violations in the exchange of porphyrins were found in 58 patients (69.0%). On the totality of the disturbances, biochemical syndromes have been identified: an increase in porphyrin precursors, uroporphyrinuria, coproporphyrinuria, urocoppororphyrinuria, combined disorders. A direct correlation was established between IL-6 (r = +0.409), IL-1Ra (r = + 0.478), IL-10 (r = + 0.456) with uroporphyrin fraction, as well as IL-1Ra and δ-pminolevulinic acid (r = + 0.501). The increase in porphyrin precursors and fractions is significantly more often detected with violations of the cytokine spectrum (χ2 = 5.6, at the critical value p = 3.8, p <0.05). Conclusion. Violations of the cytokine spectrum and porphyrin metabolism are recorded in most patients with NAFLD. The reason for their occurrence at the moment remains unclear, which requires additional research.

Цитокины сыворотки крови, экскреторный профиль порфиринового обмена, неалкогольная жировая болезнь печени, Cytokines of blood serum, excretory profile of porphyrin metabolism, non-alcoholic fatty liver disease