Role of night refluxes and serum adiponectin level in development of the gastroesophageal reflux disease in young patients with overweight

Aims: to investigate the effect of acidic night reflux and serum adiponectin level on the development of gastroesophageal reflux disease (GERD) among young patients. Objectives: to compare the clinical manifestations of GERD, the pH-metry data the frequency of pathological nocturnal acid reflux and serum adiponectin level in young people with normal and overweight. Materials and methods: the study included 62 patients with GERD at the age from 21-44 years. The study group (SG) included 31 patients with a BMI of> 25 kg / m² and the group of clinical comparison (CCG) included 31 patients with GERD with a BMI <25 kg / m². The anthropometric date and serum adiponectin level were determined. 24-hour pH-metry, upper endoscopy with polypositional biopsy were performed. Survey of patients on the severity of GERD symptoms was carried out on the basis the GerdQ questionnaire. The quality of life was assessed by the SF-36 questionnaire (The Short Form-36). To identify risk factors the case-control method was used to calculate the odds ratio (OR) and 95% confidence interval. Results: in young patients with GERD with overweight OR of developing pathological acidic night reflux were 3.4 (95% CI 1.1-10.2, p = 0.026), OR of developing pathological acid day refluxes 3.5 (95% CI 1.2-9.9, p = 0.023). In young patients with erosive form of GERD, the level of adiponectin (Me = 7.5 pg / ml) was significantly lower than in the NERB group (Me = 19.7 pg / ml) (p = 0.012). Conclusions: the article reveals that one of the risk factors for development GERD is overweight or obesity. In the pathogenesis of GERD humoral mechanisms (adipokines, in particular, adiponectin) as well as anatomical and functional factors (abdominal obesity, abnormal nocturnal acid refluxes) play role with young people which leads to development of erosive esophagitis and complications (Barrett’s esophagus).

ГЭРБ, молодой возраст, ночной рефлюкс, ожирение, адипонектин, GERD, young age, night reflux, obesity, adiponectin