Carcinogenesis in patients with non-alcoholic fatty liver disease without cirrhosis: the role of bile acids and intestinal microbiota

Abstract

The occurrence of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease without cirrhosis is of particular relevance in view of the increasing number of patients, the absence of predictors of the development of the disease and its late diagnosis. The article is devoted to the analysis of pathogenetic aspects of hepatic carcinogenesis with the participation of bile acids and intestinal microbiome and promising directions in early diagnosis and possible prevention of the disease.