AUTOIMMUNE GASTRITIS IN CHILDREN WITH TYPE 1 DIABETES

A. A. Nijevitch; G. M. Yakupova; O. A. Malievsky; V. U. Sataev; Sh. M. Khusnutdinov; D. S. Nurmukhametova; E. N. Akhmadeeva

AUTOIMMUNE GASTRITIS IN CHILDREN WITH TYPE 1 DIABETES

A. A. Nijevitch, G. M. Yakupova, O. A. Malievsky, V. U. Sataev, Sh. M. Khusnutdinov, D. S. Nurmukhametova, E. N. Akhmadeeva

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Abstract

Type 1 diabetes mellitus (DM1) and an autoimmune gastritis often occur together. Gastric autoimmunity is evident in 20% of adult patients with DM1. We screened DM1 children in Russian Federation for autoimmune gastritis. The initial cohort included 108 children with DM1 (61 female/47 male, mean age 13 ± 1,9 years) and 31 non-diabetic controls with chronic gastritis. We assessed parietal cell antibodies (APCA) presence, as well as gastric morphology. In addition, gastrin-17 and pepsinogen basal levels were measured in 42 patients with DM1 and in 31 controls. We observed APCA in 10,1% of DM1 children (7 female/4 male). All of them had DM1 for more than 10 years. A morphologic picture of autoimmune gastropathy was found in all APCA positive patients. One (out of 11) patient with APCA had a gastric colonization by Helicobacter pylori. Hypergastrinemia was diagnosed in all DM1 patients with autoimmune gastritis. Screening for gastric autoimmunity is particularly advised in children with type 1 diabetes mellitus.

Keywords

autoimmune gastritis, children, type 1 diabetes mellitus

References

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For citations:

Nijevitch A.A., Yakupova G.M., Malievsky O.A., Sataev V.U., Khusnutdinov Sh.M., Nurmukhametova D.S., Akhmadeeva E.N. AUTOIMMUNE GASTRITIS IN CHILDREN WITH TYPE 1 DIABETES. Experimental and Clinical Gastroenterology. 2016;(1):28-33. (In Russ.)

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Experimental and Clinical Gastroenterology

AUTOIMMUNE GASTRITIS IN CHILDREN WITH TYPE 1 DIABETES

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Abstract

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About the Authors

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Experimental and Clinical Gastroenterology

AUTOIMMUNE GASTRITIS IN CHILDREN WITH TYPE 1 DIABETES

Full Text:

Abstract

Keywords

About the Authors

References

Review

For citations:

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