Indicators of cellular renewal of the colon mucosa in non-alcoholic fatty liver disease
https://doi.org/10.31146/1682-8658-ecg-157-9-45-50
Abstract
Objective: To study the indicators of cellular renewal of the colon mucosa in non-alcoholic fatty liver disease (NAFLD). Materials and methods: 138 people with NAFLD and intestinal pathology were examined. The indices of proliferation (Ki-67) and apoptosis (Bcl-2) in comparison with clinical, endoscopic features of the colon and morphometric features of colonocytes expression immunopositive to leptin and the factor of vascular endothelial growth were studied. Results: It was found that changes in the intestinal mucosa and liver in NAFLD are associated with changes in the parameters of the cellular renewal of epithelial cells (the colon proliferation marker is Ki-67 and the marker of apoptosis colonocytes is Bcl-2) with changes in the production of leptin and the vascular endothelial growth factor.
About the Authors
I. V. Kozlova
Saratov State Medical University named after V. I. Razumovsky
Russian Federation
Russian Federation
E. A. Lapteva
Saratov State Medical University named after V. I. Razumovsky; FGBOU VO "Penza State University"
Russian Federation
Russian Federation
I. M. Kvetnoy
NO SRC "St. Petersburg Institute of Bioregulation and Gerontology"
Russian Federation
Russian Federation
Review
For citations:
Kozlova I.V., Lapteva E.A., Kvetnoy I.M. Indicators of cellular renewal of the colon mucosa in non-alcoholic fatty liver disease. Experimental and Clinical Gastroenterology. 2018;(9):45-50. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-157-9-45-50
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