Euthyroid sick syndrome and cytokine imbalance in pathogenesis and clinical manifestation of irritable bowel syndrome

The article presents the results of the study assessing the role of thyroid dysfunction and cytokine imbalance in the pathogenesis and manifestations of irritable bowel syndrome (IBS). We have found low serum triiodothyronine (T3) levels as well as normal or mildly reduced serum TSH levels in 44.78% IBS pts, thus confirming the presence of euthyroid sick syndrome. These changes in thyroid hormone levels were more frequent in IBS with constipation. Moreover, the IBS group was found to have elevated mean anti-TPO levels as compared with the controls. Thyroid imbalances were associated with moderately elevated pro-inflammatory (TNF-α, IL-1ß, IL-6, IL-8) cytokine levels and low levels of serum anti-inflammatory IL-10 cytokine as compared with the healthy subjects. Along with this, hypercytokinemia was less pronounced in IBS than in ulcerative colitis (UC). We have revealed relationship between clinical manifestations of IBS and the severity of thyroid dysfunction. Positive correlation was found between T3, free T4 and IL-8, while anti-inflammatory IL-10 cytokine was negatively correlated with free T3 levels. Our findings suggest that thyroid dysfunction and regulatory cytokines play a significant role in the pathogenesis and manifestations IBS and can be considered as an objective markers of disease severity. .

синдром раздраженного кишечника, синдром эутиреоидной патологии, гормоны щитовидной железы, системное воспаление, цитокины, irritable bowel syndrome, euthyroid sick syndrome, thyroid hormones, low grade systemic inflammation, cytokines