Antituberculosis Drug-Induced Hepatotoxicity

Abstract

The development of hepatotoxic reactions is one of the most common and clinically significant side effects of antituberculosis drugs (АTP). The article presents information about risk factors, pathogenetic mechanisms of the drug-induced liver injury (DILI) in chemotherapy of tuberculosis. The characteristic of АTP, with a higher incidence of hepatotoxic reactions, is given. The main principles of diagnosis and treatment of DILI induced by ATP are given. The relevance of the use of hepatoprotectors to prevent unwanted reactions of chemotherapy for tuberculosis has been noted.