New-Onset Diabetes After Liver Transplantation: Epidemiology, Risk Factors, Medical Therapy At The Outpatient Stage

Abstract

There is a higher prevalence of performed transplants of solid organs in Russia. Liver transplantation (LT) is the most effective way to treat liver diseases at advanced stages, and for many patients -the only effective one. Marked improvement in the surgery leads to the advances in LT techniques and the increase of overall number of LTs performed. However the number of recipients with metabolic disorders requiring medical interventions increases as well. LT can be accompanied by several complications. The most common one is diabetes mellitus (DM). New onset DM after LT increases the risk of transplant rejection, infection, adverse cardiovascular outcomes and reduces the survival of patients. An early diagnostics of carbohydrate metabolism disturbances in patients who underwent LT might be achieved with rigorous identification of the risk factors associated with DM development after and proper screening performed before the intervention. Beyond these, in a particular group of solid organs recipients a rational administration of drug therapy for DM, which is based on evidence of treatment outcome, safety and drug interactions with immunosuppressive therapy, should improve the number of adverse outcomes and contribute to effective blood glucose control in a postoperative period after LT.