Non-Alcoholic Fatty Liver Disease With Endocrine Diseases In Children And Adolescents

Abstract

Currently, non-alcoholic fatty disease is one of the frequent liver diseases not only in adults, but also in adolescents and even children. The growth of this pathology is associated with an increase in the number of patients suffering from obesity, diabetes, insulin resistance. Studies on fatty liver degeneration with insulin-dependent diabetes mellitus (type 1) are not enough. The aim of the study was to evaluate and compare laboratory and instrumental data in children with non-alcoholic fatty liver disease in endocrinological pathology. The article presents the results of a survey of 67 children and adolescents with fatty hepatosis (41 children with type 1 diabetes and 27 with obesity). It was shown that in children with obesity, an increase in alanine transaminase was significantly more frequent in comparison with the group of children with diabetes (p=0,047). There was a trend towards a more frequent increase in triglycerides, cholesterol and low-density lipoproteins and children with diabetes, but no significant differences were found in the groups. According to the results of ultrasound examination of the abdominal cavity organs, all patients showed signs characteristic of fatty hepatosis, without significant differences in groups.