Characteristics Of Indicators Of The System Of Hemostasis In Patients With Fibrosis And Cirrhosis Of The Liver

Abstract

The aim was to investigate hemostasis system in patients with liver fibrosis and cirrhosis. Materials and methods. We examined 10 patients with liver fibrosis, 25 patients with liver cirrhosis and 10 healthy people. Primary and secondary hemostasis and Hageman-factor-dependent fibrinolysis were studied. Results. Patients with liver fibrosis had decreased platelets aggregation with inductors, but normal platelet count. Also, they had increased thrombin time (TT) and activated partial thromboplastin time (APTT), but normal prothrombin index (PTI). Patients with liver cirrhosis had thrombocytopenia and decreased platelets aggregation, increased TT and APTT, but decreased PTI. Time of the Hageman-factor-dependent fibrinolysis was increased in patients with liver cirrhosis. Conclusion. Patients with liver fibrosis and cirrhosis have disturbances in primary and secondary hemostasis and patients with liver cirrhosis have decreased activity of Hageman-factor-dependent fibrinolysis. Probably, it could be determined by hepatocytes function failure and/or disseminated intravascular coagulation.