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Experimental and Clinical Gastroenterology

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Human microbiote: how a new scientific paradigm changes medical practice

https://doi.org/10.31146/1682-8658-ecg-161-1-55-63

Abstract

Microbiota plays a key role in the physiology and maintenance of homeostasis of the human body. The importance belongs to the processes of the formation of the intestinal microbiota, starting in utero, and the child continues to receive the mother’s microflora during childbirth and breastfeeding. The results of molecular genetic studies indicate that the most intensive process of microbial colonization in infant is associated with features of feeding. The main factor in maintaining the stability and resistance of normal biota is microbial autometabiolites. Considered the most promising probiotic biotechnology and development metabolic of probiotics (metabiotics) probiotics in combination with Prebiotics (synbiotics). Understanding the processes of formation of intestinal microflora allows you to develop effective methods of prevention and correction micro-ecological and motor disorders in the age aspect.

About the Authors

L. A. Kharitonova
Pirogov Russian National Research Medical University (RNRMU)
Russian Federation


K. I. Grigoriev
Pirogov Russian National Research Medical University (RNRMU)
Russian Federation


S. N. Borzakova
Pirogov Russian National Research Medical University (RNRMU)
Russian Federation


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For citations:


Kharitonova L.A., Grigoriev K.I., Borzakova S.N. Human microbiote: how a new scientific paradigm changes medical practice. Experimental and Clinical Gastroenterology. 2019;(1):55-63. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-161-1-55-63

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ISSN 1682-8658 (Print)