MICROBIOTHERIA AND MOTOR DISORDERS OF THE GASTROINTESTINAL TRACT IN SEVERE ATOPIC DERMATITIS IN CHILDREN

The materials and methods. In total, the study included 41 children with atopic dermatitis in the average age of 10.95 ± 0,51 years (5-16 years), 20 boys and 21 girl, with a SCORAD index above 45, i. e., a severe disease. Patients the study was conducted in the electrical activity of the digestive system using the peripheral electrogastroenterography method (PAGEG), as well as the study of the content of short chain fatty acids (SHQ) to the chair by means of high performance liquid chromatography. The results of the study. In children with AD was observed discomfort in the abdomen (from 92.7% of children), also in more than half cases was observed (in descending order) rumbling in the abdomen, abdominal pain, flatulence, nausea. It was found a significant increase of the average values of the coefficient of rhythm and a tendency to increase the relative strength of the duodenum). In the colon on an empty stomach these parameters were generally reduced, which points to geometric. SHQ spectrum disorders, reflecting the metabolic activity of the intestinal microflora, was characterized by the increase in almost all children’s products by the microorganisms of the intestine acetic, propionic, butyric, valeric acid, and isovaleric acid, while significant increase in the level of isoacid production.

SCORAD, atopic dermatitis, SCORAD, bowel motility, peripheral electrogastrogram, short-chain fatty acids in stool, intestinal microbiocenosis

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