MARKERS OF SYSTEMIC INFLAMMATION IN PATHOGENESIS AND OPTIMIZATION OF PHARMACOTHERAPY OF IRRITABLE BOWEL SYNDROME
Abstract
In the presented article the data gained from recent publications and our original investigations conducted in term to determine the role of low grade systemic inflammation in the pathogenesis and clinical manifestation of irritable bowel syndrome (IBS) were analyzed. It was shown that in patients with IBS levels of circulating key pro-inflammatory cytokines (TNFα, IL-1, IL-6, IL-8) were increased while the levels of anti-inflammatory IL-10 tends to decrease. Revealed cytokine imbalance correlated with severity of the intestinal symptoms such as abdominal pain and changes in bowel habits. The raised levels of pro-inflammatory cytokines were detected in 30-40 % pts with IBS and in 60-85 % pts with ulcerative colitis (UC) versus 2-6 % in controls. In pts with active UC pro-inflammatory cytokines raised much more prominent than in IBS, nevertheless in IBS group levels of these cytokines were significantly higher than in controls. The results of randomized placebo controlled study had demonstrated the efficacy and safety of combination of affinity purified release-active antibodies (RAAT) to histamine, TNFα and brain-specific S-100 protein with anti-cytokine property in the treatment of IBS. In pts treated with combination of affinity purified RAAT to histamine, TNF-α and brain-specific S-100 protein the significant improvement in intestinal and non-intestinal systemic symptoms was registered. These data support the concept of relationship between cytokine imbalance and functional GI disorders and suggest the recommendation to include combination of affinity purified RAAT to histamine, TNF-α and brain-specific S-100 protein as disease modifying drug in IBS treatment.
About the Authors
A. R. Babaeva
Volgograd state medical University
Russian Federation
Russian Federation
M. A. Osadchuk
First Moscow state medical University. I. M. Sechenov, the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
R. V. Vidiker
Volgograd state medical University
Russian Federation
Russian Federation
E. V. Kalinina
Volgograd state medical University
Russian Federation
Russian Federation
K. S. Solodenkova
First Moscow state medical University. I. M. Sechenov, the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Babaeva A.R., Osadchuk M.A., Vidiker R.V., Kalinina E.V., Solodenkova K.S. MARKERS OF SYSTEMIC INFLAMMATION IN PATHOGENESIS AND OPTIMIZATION OF PHARMACOTHERAPY OF IRRITABLE BOWEL SYNDROME. Experimental and Clinical Gastroenterology. 2017;(3):48-55. (In Russ.)
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