BENIGN AND MALIGNANT NEOPLASMS OF THE GASTROINTESTINAL TRACT IN PATIENTS WITH ACROMEGALY
Abstract
Acromegaly is a severe neuroendocrine disease caused by increased production of somatotropic hormone by adenohypophysis tumor. The somatotropic hormone is indirectly, via insulin-like growth factor-1, acts on all organs and systems of the body, causing a large number of complications, including those of the gastrointestinal tract. Numerous cases of diagnosing both benign and malignant neoplasms have been described in the literature in this group of patients. About 15% of patients with acromegaly die from cancer, especially colon cancer, which frequency varies from 2 to 14 times the increase in comparison with the general population. However, there is an extremely low amount of studies of the upper part of the digestive tract in patients with acromegaly. The article reflects the results of various domestic and foreign studies on the upper and lower divisions of the gastrointestinal tract of patients with acromegaly, malignant and benign neoplasms of the stomach and colon, diverticular disease in patients with acromegaly, as well as possible prerequisites for their development, based on the pathogenesis of the underlying disease.
About the Authors
A. A. Titaeva
Moscow regional scientific and clinical research Institute named after M. F. Vladimirsky
Russian Federation
Russian Federation
E. A. Belousova
Moscow regional scientific and clinical research Institute named after M. F. Vladimirsky
Russian Federation
Russian Federation
S. G. Tereshchenko
Moscow regional scientific and clinical research Institute named after M. F. Vladimirsky
Russian Federation
Russian Federation
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For citations:
Titaeva A.A., Belousova E.A., Tereshchenko S.G. BENIGN AND MALIGNANT NEOPLASMS OF THE GASTROINTESTINAL TRACT IN PATIENTS WITH ACROMEGALY. Experimental and Clinical Gastroenterology. 2018;(6):94-97. (In Russ.)
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