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ALCOHOL ASSOCIATED INTERNAL INJURY IN RATS

Abstract

Purpose. Experimentally determine the volume and time stages of damage formation associated with the use of low-alcohol (SAN) and energy drinks (EN) in rats. Material and methods. 45 white Wistar rats were used, the experimental animals were divided into three series consisting of three groups. The first a series of age - 1.5 month; the second a series of - 12 months. The third series-24 months. In each series of 3 groups: 1-I control (intact), animals had the free access to clean water and customary food. 2nd experimental group rats with free access to water and food was added to the drinking bowl with AL “Red Bull” or SAN “Black Russian”. Autopsy after 14 and 45 days, or if necessary, when the animals died from drinking. After the autopsy, the abdominal and thoracic cavities were examined. To assess the revealed injuries, the damage index (di) was calculated, which was calculated by the number of organs with injuries and divided by the number of animals in the group. Conclusion. Experimental animal studies have established a single pathogenetic mechanism and cause-and-effect relationship between blood flow disorders associated with alcohol and multiple (polymorbidity) internal injuries. Low-alcohol drinks (cocktails) are not harmless drinks, they cause multiple toxic damage to the internal organs in the “young” rats appear damage characteristic of the “old” animals. In this case, aging is not age, but disease. Low-alcohol and energy drinks are conducive to the use of stronger drinks (“Rare” - Red bull + vodka). Decrease in the instinct of self-preservation-refusal of food and drink in combination with polymorbidity of lesions of internal organs leads to death of animals. Easy access for young people and the widespread availability of low-alcohol and energy drinks (cocktails) are a subject of discussion and attention for educators and doctors.

About the Authors

I. E. Trubitsyna
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


T. F. Fedotova
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


I. V. Mikhalev
Moscow Research and Practical Centre for Narcology of the Department of Public Health
Russian Federation


L. I. Efremov
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


V. N. Kleschev
Federal State Budgetary Educational Establishment of Higher Education Russian State University of Physical Education, Sport, Youth and Tourism
Russian Federation


V. V. Kleschev
Federal State-Funded Educational Institution of Higher Education "Financial University under the Government of the Russian Federation"
Russian Federation


S. F. Mikhailova
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


L. V. Vinokurova
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


D. A. Degterev
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


G. G. Varvaina
Moscow clinical scientific and practical center. A. S. Loginov
Russian Federation


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Review

For citations:


Trubitsyna I.E., Fedotova T.F., Mikhalev I.V., Efremov L.I., Kleschev V.N., Kleschev V.V., Mikhailova S.F., Vinokurova L.V., Degterev D.A., Varvaina G.G. ALCOHOL ASSOCIATED INTERNAL INJURY IN RATS. Experimental and Clinical Gastroenterology. 2018;(6):90-93. (In Russ.)

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ISSN 1682-8658 (Print)