THE CHANGE OF INTESTINAL MICROFLORA IN NONSTEROIDAL ANTI-INFLAMMATORY DRUG ACETAMINOPHEN ADMINISTRATION
Abstract
Objective: To study the qualitative and quantitative composition of microflora in the jejunum and the cecum in acetaminophen administration. Materials and methods: The experiments were carried out on 30 rats male Wistar rats weighing 400-450 g. The influence of intragastric administration of acetaminophen (500 mg/kg) on the microflora in the jejunum and cecum has been studied. Results: It is shown that administration of acetaminophen within 21 days no changes composition of the jejunal microbiota, but leads to decrease species composition and to significant inhibition of lactobacillus and bifidobacterium in the cecum.
About the Authors
N. S. Tropskaya
N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare
Russian Federation
Russian Federation
I. G. Vilkova
N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare
Russian Federation
Russian Federation
E. A. Kislykova
N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare
Russian Federation
Russian Federation
O. S. Kislicina
N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare
Russian Federation
Russian Federation
T. V. Chernen’Kaya
N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare
Russian Federation
Russian Federation
T. S. Popova
N. V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Healthcare
Russian Federation
Russian Federation
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Review
For citations:
Tropskaya N.S., Vilkova I.G., Kislykova E.A., Kislicina O.S., Chernen’Kaya T.V., Popova T.S. THE CHANGE OF INTESTINAL MICROFLORA IN NONSTEROIDAL ANTI-INFLAMMATORY DRUG ACETAMINOPHEN ADMINISTRATION. Experimental and Clinical Gastroenterology. 2018;(6):86-89. (In Russ.)
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