OVERLAP SYNDROME OF GERD AND DYSPEPSIA
Abstract
Aim. To study the overlap syndrome of GERD and dyspepsia in a population study. Methods: A clinical and epidemiological study was performed, during which 1411 adult patients (506 indigenous and 905 alien inhabitants) were examined in an organized population with a coverage of 93%. Results. The prevalence of weekly heartburn was 12.2% in Caucasians and 8.3% in Khakassians (p = 0.03). Dyspepsia was detected in 20.2% of alien inhabitants and in 15.8% of indigenous people (p = 0.05). Dyspepsia was registered 7.1 times more often in Caucasians with weekly heartburn (p <0.001) and 6.3 times more often in the same group of Khakassians (p <0.001) compared to those without heartburn. Conclusions. It was concluded that there is overlap syndrome of GERD and dyspepsia in indigenous and alien inhabitants of Khakassia.
About the Authors
V. V. Tsukanov
Federal State Budgetary Scientific Institution “Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science” (FRC KSC SB RAS), “Scientific Research Institute of medical problems of the North” (SRI MPN)
Russian Federation
Russian Federation
A. V. Vasyutin
Federal State Budgetary Scientific Institution “Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science” (FRC KSC SB RAS), “Scientific Research Institute of medical problems of the North” (SRI MPN)
Russian Federation
Russian Federation
J. L. Tonkikh
Federal State Budgetary Scientific Institution “Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science” (FRC KSC SB RAS), “Scientific Research Institute of medical problems of the North” (SRI MPN)
Russian Federation
Russian Federation
O. S. Rzhavicheva
NUZ Road Clinical Hospital
Russian Federation
Russian Federation
N. N. Butorin
Federal State-Funded Educational Institution of Higher Professional Education “Katanov Khakass State University”
Russian Federation
Russian Federation
O. V. Peretyatko
Federal State Budgetary Scientific Institution “Federal Research Centre “Krasnoyarsk Science Centre” of the Siberian Branch of Russian Academy of Science” (FRC KSC SB RAS), “Scientific Research Institute of medical problems of the North” (SRI MPN)
Russian Federation
Russian Federation
References
1. Park K.S., Jee S. R., Lee B. E. et al. Nationwide Multicenter Study for Overlaps of Common Functional Gastrointestinal Disorders in Korean Patients With Constipation // J. Neurogastroenterol. Motil. - 2017. - Vol. 23, № 4. - P. 569-577
2. Richter J.E., Rubenstein J. H. Presentation and Epidemiology of Gastroesophageal Reflux Disease // Gastroenterology. - 2018. - Vol. 154, № 2. - P. 267-276.
3. Eusebi L.H., Ratnakumaran R., Bazzoli F., Ford AC. Prevalence of Dyspepsia in Individuals With Gastroesophageal Reflux-Type Symptoms in the Community: A Systematic Review and Meta-analysis // Clin. Gastroenterol. Hepatol. - 2018. - Vol. 16, № 1. - P. 39-48.
4. Takeuchi T., Takahashi Y., Kawaguchi S. et al. Therapy of gastroesophageal reflux disease and functional dyspepsia overlaps with symptoms after usual-dose proton pump inhibitor: Acotiamide plus usual-dose proton pump inhibitor versus double-dose proton pump inhibitor // J. Gastroenterol. Hepatol. - 2018. - Vol. 33, № 3. - P. 623-630.
5. Vakil N., van Zanten S. V., Kahrilas P. et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus // Am J Gastroenterol. - 2006. - Vol.101, № 8. - P. 1900-1920.
6. Tack J., Talley N. J., Camilleri M. et al. Functional gastroduodenal disorders // Gastroenterology. - 2006. - Vol. 130, № 5. - P. 1466-1479.
7. Talley N.J., Vakil N. B., Moayyedi P. American gastroenterological association technical review on the evaluation of dyspepsia // Gastroenterology. - 2005. - Vol. 129, № 5. - P. 1756-1780.
8. Ghoshal U.C., Singh R., Chang F. Y. et al. Epidemiology of uninvestigated and functional dyspepsia in Asia: facts and fiction // J. Neurogastroenterol. Motil. - 2011. - Vol. 17, № 3. - P. 235-244.
9. Aziz I., Palsson O. S., Törnblom H. et al. Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study // Lancet Gastroenterol. Hepatol. - 2018. - Vol. 3, № 4. - P. 252-262.
10. Штыгашева О.В., Цуканов В. В. Ассоциация Саg A и Vac A штаммов Helicobacter Pylori и язвенной болезни в организованной популяции г. Абакана // Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. -2004. - Т. 14, № 2. - С. 84-87.
11. Агеева Е.С., Штыгашева О. В., Рязанцева Н. В., Цуканов В. В. Молекулярно-генетические факторы, влияющие на исход инфицирования Helicobacter Pylori у жителей республики Хакасия // Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. - 2010. - Т. 20, № 4. - С. 16-21
12. Цуканов В.В., Хоменко О. В., Ржавичева О. С. и др. Распространенность Helicobacter Pylori и ГЭРБумонголоидов и европеоидов Восточной Сибири // Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. - 2009. - Т. 19, № 3. - С. 38-41
13. Rasmussen S., Jensen T. H., Henriksen S. L. et al. Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population // Scand. J. Gastroenterol. - 2015. - Vol. 50, № 2. - P. 162-169
14. Min B.H., Huh K. C., Jung H. K. et al. Prevalence of uninvestigated dyspepsia and gastroesophageal reflux disease in Korea: a population-based study using the Rome III criteria // Dig. Dis. Sci. - 2014. - Vol. 59, № 11. - P. 2721-2729
15. Hsu C.S., Wen S. H., Hung J. S. et al. Overlap of Dyspepsia in Patients with Gastroesophageal Reflux Disease: Impact of Clinical, Metabolic, and Psychosocial Characteristics // Dig. Dis. Sci. - 2017. - Vol. 62, № 4. - P. 994-1001
Review
For citations:
Tsukanov V.V., Vasyutin A.V., Tonkikh J.L., Rzhavicheva O.S., Butorin N.N., Peretyatko O.V. OVERLAP SYNDROME OF GERD AND DYSPEPSIA. Experimental and Clinical Gastroenterology. 2018;(6):36-39. (In Russ.)
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