HELICOBACTER PYLORI PHOTODYNAMIC INACTIVATION IN VITRO WITH ZINC OCTAKIS (CHOLINYL) PHTHALOCYANINE
Abstract
Helicobacter pylori, an etiopathogenetic factor of gastritis and gastric and duodenal ulcer disease, is highly sensitive in vitro to antimicrobial photodynamic therapy with zinc octakis(cholinyl)phthalocyanine (o-PCZ). The photosensitizing activity of o-PCZ with molecules bearing eight positively charged substituents, is due to electrostatic binding with negatively charged surface of the cell walls of bacteria. In the bound state, when excited by light, o-PCZ generates singlet oxygen, which has a bactericidal effect. Intensive absorption of o-PCZ in the far-red region of the spectrum allows to use in photodynamic therapy light of wavelengths with high penetrating capacity in the biological environment from led sources.
About the Authors
V. G. Zhukhovitsky
Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Public Health; Sechenov The First Moscow Medical University, Ministry of Public Health
Russian Federation
Russian Federation
E. G. Kholina
Lomonosov Moscow State University
Russian Federation
Russian Federation
M. G. Strakhovskaya
Lomonosov Moscow State University; Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
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Review
For citations:
Zhukhovitsky V.G., Kholina E.G., Strakhovskaya M.G. HELICOBACTER PYLORI PHOTODYNAMIC INACTIVATION IN VITRO WITH ZINC OCTAKIS (CHOLINYL) PHTHALOCYANINE. Experimental and Clinical Gastroenterology. 2018;(6):10-15. (In Russ.)
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