PROGNOSTIC VALUE OF CONNECTIVE TISSUE DISPLASIA IN DUODENOGASTROESOPHAGEAL REFLUX-ASSOCIATED GASTROESOPHAGEAL REFLUX DISEASE

Abstract

In 129 patients with DGER-associated GERD, aged 18-76 years, the presence and severity of phenotypic and visceral signs СTD were recorded using the original screening kit, which detects them in adult patients. Dysplastic-dependent phenotype was diagnosed in 59 people (15 men and 44 women), absence of signs of CTD - in 70 (27 men and 43 women). Among the phenotypic signs of CTD in patients with GERD predominate musculocutaneous (47,9%), osteoarticular (27,5%) and cranial (18,5%). Among visceral symptoms dominated cardia insufficiency (57,6%), hiatal hernia (HH) (54,2%), the structure anomalies of gallbladder (39,0%). Regardless of the sex of patients, the severity of CTD was moderate. Chance of developing DGER-associated GERD, in patients with dysplastic-dependent phenotype was 3,7 times higher compared with individuals with no evidence of CTD in the presence of HH; 1,4-1,6 times - with cardia insufficiency, abnormal forms of gallbladder and their combination; 4,3 times - with combination of HH and an abnormal forms of gallbladder. In the adult population of patients with DGER-associated GERD in 45,7% of cases it occurs on the background of the high frequency of phenotypic and visceral manifestations of CTD. Visceral manifestations (HH, cardia insufficiency, abnormal forms of the gallbladder, and others) at high frequency of phenotypic signs appear predictors of GERD associated with DGER.