ETIOLOGY, MECHANISMS OF REGULATION OF THE MORPHOFUNCTIONAL STATE OF THE ESOPHAGUS AND PATHOGENESIS OF CHRONIC ESOPHAITIS
Abstract
Taking into account the action of endogenous and exogenous risk factors, to discuss mechanisms for regulating the morphofunctional state of the esophagus and the pathogenesis of HE at the cellular, intercellular, organ and systemic levels. The work is based on the analysis of literature data and the results of long-term studies of the author and employees of the Department of faculty therapy, conducted in 689 patients with clinical and morphological manifestations of HE. 124 of them were treated for GERD with reflux esophagitis (re) associated with chronic gastritis (CG), 129 for GERD and re due to biliary pathology, 181 for exacerbation of CG, 223 for recurrence of peptic ulcer disease (NAF) and 32 for non-comorbidities. Among patients with GERD and re in Association with CG, there were 61 males and 63 females, aged 30-60 years, and with GERD and re in biliary pathology, 42 males and 87 females in 86% of cases. Pathogenesis of the disease in the detection of risk factors associated with the violation of the regulatory systems of the body and interaction at the cellular, intercellular, organ, organ and systemic levels, leading to a decrease in multi-level protection mechanisms and the development of morphofunctional changes in the esophagus.
About the Author
V. V. Chernin
Tver state medical university, department of faculty therapy
Russian Federation
Russian Federation
References
1. Pimanov S. I. Ezofagit, gastrit, yazvennaya bolezn: rukovodstvo dlya vrachei. M., 2000. - S. 78-134.
2. Maev I. V. Gastroezofagealnaya refyuksnaya bolezn - bolezn HHI veka. // Lechaschii vrach - 2004. - № 4. - S. 10-14.
3. Osadchuk M. A., Osadchuk M. M. Kliniko-endoskopicheskie i morfofunkcionalnie pokazateli v ocenke razvitiya gastroezofagealnoi reflyuksnoi bolezni // Ross. jurn. Gastroenter., gepatol., koloproktol. 2005. - № 5. - S. 12.
4. Lazebnik L. B., Scherbakov P. L. Gastroenterologiya. M., «MK», 2011. - S. 14-78.
5. Ivashkin V. T., Maev I. V., Truhmanov A. S. Pischevod Barretta. M., «Shiko», 2011. - T. 1. - 608 s.
6. Vasilenko V. H., Grebenev A. L., Salman M. M. Bolezni pischevoda. M., «Medicina», 1971. - 407 s.
7. Grigorev P. Ya., Yakovenko E. P. Diagnostika i lechenie yazvennoi bolezni i aktivnogo helikobakterialnogo gastroduodenita. // Russk. med. jurnal. - 1996. - S. 51-55.
8. Grigorev P. Ya., Yakovenko E. P. Profilaktika i lechenie boleznei organov pischevareniya. M., 2000. - 119 s.
9. Vasilev Yu. V. Gastroezofagealnaya reflyuksnaya bolezn v stadii reflyuks-ezofagita: diagnostika i terapiya // Farmateka, 2004. - № 13. - S. 1-5.
10. Cimmerman Ya.S., Cimmerman I. Ya. Klassifikacii gastroduodenalnih zabolevanii i klinicheskih sindromov. Perm, 2014. - 153 s.
11. Chernin V. V., Sekareva E. V. Ezofagiti. V aspekte narushenii regulyatornih sistem. Tver; 2017. - 268 s.
12. Bordin D. S., Lazebnik L. B., Masharova A. A. Gastroezofagealnaya reflyuksnaya bolezn u pojilih. / Gastroenterologiya (Bolezni vzroslih). M., 2011. - S. 58-78.
13. Dzhulaj G. S., Sekareva E. V. Gastrojezofageal’naja refljuksnaja bolezn’ i soedinitel’no-tkannye displazii v aspekte premorbidnosti i komorbidnosti // Jeksperim. i klinich. gastrojenterol. - 2014. - Vyp. 102. - № 2. - S. 16-20.
14. Machabeli M. S. Trombo-gemorragicheskij sindrom kak obshhepatologicheskaja zakonomernost’ adaptacionnogo haraktera // Laborat. delo. - 1969. - № 8. - S. 451-455.
15. Maev I. V. Pishhevod Barretta. Gastrojenterologija. M., 2011. - S. 14-58.
16. Truhmanov A. S. Gastrojezofageal’naja refljuksnaja bolezn’: klinika, diagnostika, lechenie./ Bolezni organov pishhevarenija, 2001. - № 3. - S. 19-24.
17. Chernin V. V., Parfenov A. I., Bondarenko V. M. Rybal’chenko O.V., Chervinec V. M. Simbiontnoe pishhevarenie cheloveka. Fiziologija, klinika, diagnostika i lechenie ego narushenij. Tver’: «Triada»; 2013. 232 s.
18. Ugolev A. M. Jevoljucija pishhevarenija i principy jevoljucii funkcij. L.: «Nauka»; 1985. 544 s.
19. Chernin V. V. Kliniko-jeksperimental’nye aspekty patogeneza, sanogeneza i lechenija jazvennoj bolezni. Tver’; 1994. 255 s.
20. Chernin V. V. Bolezni pishhevoda, zheludka i dvenadcatiperstnoj kishki. M.: «MIA»; 2010. 528 s.
21. Korot’ko G. F. Fiziologija organov pishhevarenija. Krasnodar; 2009. 667 s.
22. Chernin V. V. Jazvennaja bolezn’. Tver’; 2000. 287 s.
23. Chernin V. V. Hronicheskij gastrit. Tver’: «Triada»; 2006. 302 s.
Review
For citations:
Chernin V.V. ETIOLOGY, MECHANISMS OF REGULATION OF THE MORPHOFUNCTIONAL STATE OF THE ESOPHAGUS AND PATHOGENESIS OF CHRONIC ESOPHAITIS. Experimental and Clinical Gastroenterology. 2018;(3):41-46. (In Russ.)
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