SACCHAROMYCES BOULARDII MODULATES THE COMPOSITION OF THE GUT MICROBIOTA IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE, THUS PREVENTING THE PROGRESSION OF THE DISEASE

25 adult patients with NAFLD (steatosis only) were enrolled in the study. The quantitative real-time polymerase chain reaction (qRT-PCR) was used for fecal microbiota assessment. All patients were treated with oral lyophilized Saccharomyces boulardii for 90 days (3 capsules 250 mg per day). The count of Escherichia coli in patients with NAFLD steatosis was initially higher than the reference values obtained from healthy volunteers. Lyophilized S. boulardii for 90 days significantly reduced Bacteroides fragilis group and Escherichia coli. There were no significant changes in other fecal microbiota (total bacterial count, Lactobacillus group, Bifidobacterium spp., Faecalibacterium prausnitzii, etc.). Treatment with S. boulardii improved symptoms and quality of life in patients with NAFLD steatosis and significantly reduced VLDL and atherogenic index. Patients with overweight or obesity showed a decrease in body weight. In all patient steatosis showed no progression as assessed by FibroMax test, liver ultrasonography and telomere test Saccharomyces boulardii significantly reduced initially elevated fecal Escherichia coli in patients with NAFLD steatosis to normal values, thus reducing the risk of additional liver damage by endogenous ethanol and inhibiting the choline deficiency. S. boulardii significantly lowered Bacteroides fragilis group, thus reducing the risk of endotoxemia. The lack of progression of steatosis after 90 days suggests the effectiveness of S. boulardii in patients with NAFLD. Lyophilized Saccharomyces boulardii modulates the composition of the gut microbiota in patients with NAFLD steatosis and restores intestinal barrier integrity, thus preventing the progression of the disease.

Escherichia coli, Saccharomyces boulardii, Bacteroides fragilis group, butyrate, butyric acid, dysbiosis, Escherichia coli, gut microbiota, NAFLD, non-alcoholic fatty liver disease, psyllium, Saccharomyces boulardii, steatosis

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