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STUDY OF THE MORPHOLOGICAL AND PHYSIOLOGICAL PROPERTIES OF ERYTHROCYTES IN THE CHILDREN WITH CROHN’S DISEASE

Abstract

The study was conducted in 17 patients with CD at the age of 10 to 17 years. The erythrocyte deformability, aggregate morphology in autologous plasma, state of membrane cytoskeleton and cell aggregation induced by lanthanum were studied. In patients with CD significant changes of average erythrocyte deformability and changes in distribution of the cell number for the degree of their deformability were revealed. Morphological pattern of erythrocyte aggregation was changed - along with the formation of «rouleaux» aggregates globular structures (clump) appeared. The stability of the erythrocyte cytoskeleton significantly decreases. Studying of human erythrocyte aggregation induced by lanthanum was shown that erythrocyte aggregation of patients at studied lanthanum concentration significantly different from normal cell aggregation. Current treatment resulted in improvement of rheological and membrane erythrocyte properties. However, complete normalization of erythrocyte properties did not occur. The results show significant changes in the rheological and membrane properties of erythrocytes in children with CD. Determination of rheological and membrane properties of erythrocytes allow to obtain additional information on the process of the disease and the effectiveness of its treatment.

About the Authors

Yu. A. Sheremet’Ev
«Privolzhsky Federal Research Medical Centre» of the Ministry of Health of the Russian Federation
Russian Federation


A. N. Popovicheva
«Privolzhsky Federal Research Medical Centre» of the Ministry of Health of the Russian Federation
Russian Federation


G. Ya. Levin
«Privolzhsky Federal Research Medical Centre» of the Ministry of Health of the Russian Federation
Russian Federation


E. N. Fedulova
«Privolzhsky Federal Research Medical Centre» of the Ministry of Health of the Russian Federation
Russian Federation


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For citations:


Sheremet’Ev Yu.A., Popovicheva A.N., Levin G.Ya., Fedulova E.N. STUDY OF THE MORPHOLOGICAL AND PHYSIOLOGICAL PROPERTIES OF ERYTHROCYTES IN THE CHILDREN WITH CROHN’S DISEASE. Experimental and Clinical Gastroenterology. 2018;(1):50-55. (In Russ.)

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ISSN 1682-8658 (Print)