THE ROLE OF INTESTINAL-BRAIN AXIS IN THE PATHOGENESIS OF DISEASES ASSOCIATED WITH Helicobacter Pylori
Abstract
A complex combination of external factors (stress), host immune status and virulence factors determines the susceptibility and severity of the outcome of H. pneumonia infection and associated pathology. H.pylori and intestinal-brain axis relationships are bi-directional and affect the infection process and neuroendocrine immunological response of the host organism, including changes in secretory and motor functions of the digestive tract, modification of visceral sensitivity and cognitive functions. The effect of H.pylori on intestinal-brain axis is based on direct neurotoxic action, micronutrient deficiency, the activation of inflammatory processes in the epithelium, destruction of the barrier function, destabilization of the blood-brain barrier and the systemic action of pro-inflammatory cytokines.
About the Authors
E. V. Ryabichenko
Federal research center of epidemiology and Microbiology them. N. F. Gamalei
Russian Federation
Russian Federation
O. A. Burgasov
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
V. G. Zhukhovitskii
Federal research center of epidemiology and Microbiology them. N. F. Gamalei; First MSMU n. a. I. M. Sechenov
Russian Federation
Russian Federation
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Review
For citations:
Ryabichenko E.V., Burgasov O.A., Zhukhovitskii V.G. THE ROLE OF INTESTINAL-BRAIN AXIS IN THE PATHOGENESIS OF DISEASES ASSOCIATED WITH Helicobacter Pylori. Experimental and Clinical Gastroenterology. 2017;(12):4-8. (In Russ.)
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