CIRCULATING NEUTROPHIL EXTRACELLULAR TRAPS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH SUPPURATIVE COMPLICATION

Objective of the Paper: Quantitative comparison of neutrophil extracellular traps (NETs) in blood between type 2 diabetes mellitus patients with purulent necrotic complications at various locations and healthy volunteers. Key Points: NETs concentration in patient blood was, on average, higher than that for healthy subjects. NETs blood concentration in the latter and in patients (n = 5) with high levels of NETs increased as HbA1c increased. For other patients, NETs concentration decreased as HbA1c increased, indicating the existence of a compensatory mechanism to inhibit NETosis in conditions of inflammation in type 2 diabetes mellitus. High NETs levels and a positive correlation between this parameter and HbA1c were observed in patients with phlegmon, vast infected wound, gangrene of lower leg, purulent pyogenic mediastinitis. Infected wounds, abscess, gangrene of finger were predominant among other patients. Analysis of the two clinical examples shows the relationship between inflammation severity, including wound healing speed, and NETs concentration in patient blood. Conclusion: This study suggests that monitoring blood levels of NETs alongside HbA1 levels in healthy subjects and type 2 diabetes mellitus patients with allow more accurate assessment of the risk of various complications, the disease severity and the duration of post-surgical treatment

type 2 diabetes mellitus, NETosis, glycated haemoglobin, purulent necrotic complications, neutrophil extracellular traps

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