THE INVESTIGATION OF ASSOCIATION POLYMORPHISMS OF XENOBIOTICS BIOTRANSFORMATION ENZYMES GENES EPHX1 AND CYP1A1 TO THE DEVELOPMENT OF ACUTE PANCREATITIS IN RUSSIANS
Abstract
The aim of this study was to investigate the relationship between polymorphisms H139R and I462V of genes EPHX1 and CYP1A1 in the development of acute pancreatitis (AP) in the Russian population. Whole blood samples were collected from 299 patients with acute pancreatitis and 238 healthy controls. Genotyping of the SNPs (rs2234922) EPHX1 gene and (rs1048943) CYP1A1 gene accomplished using PCR with allele discrimination using TaqMan-probes. It has been found that the allele 139H (OR = 1.34 95 % CI 1.03-1.75) associated with a reduced risk of acute pancreatitis. I462V polymorphism association with development of acute pancreatitis detected. Conducted stratified analysis of smoking and genotypes of polymorphisms H139R and I462V genes EPHX1 and CYP1A1 in the development of acute pancreatitis also found no differences in the groups of patients and healthy controls.
About the Authors
T. A. Samgina
Federal public budgetary educational institution of higher education “Kursk State Medical University” of the Ministry of Healthcare of the Russia
Russian Federation
Russian Federation
O. Y. Bushueva
Federal public budgetary educational institution of higher education “Kursk State Medical University” of the Ministry of Healthcare of the Russia
Russian Federation
Russian Federation
P. M. Nazarenko
Federal public budgetary educational institution of higher education “Kursk State Medical University” of the Ministry of Healthcare of the Russia
Russian Federation
Russian Federation
A. V. Polonikov
Federal public budgetary educational institution of higher education “Kursk State Medical University” of the Ministry of Healthcare of the Russia
Russian Federation
Russian Federation
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Review
For citations:
Samgina T.A., Bushueva O.Y., Nazarenko P.M., Polonikov A.V. THE INVESTIGATION OF ASSOCIATION POLYMORPHISMS OF XENOBIOTICS BIOTRANSFORMATION ENZYMES GENES EPHX1 AND CYP1A1 TO THE DEVELOPMENT OF ACUTE PANCREATITIS IN RUSSIANS. Experimental and Clinical Gastroenterology. 2017;(11):34-37. (In Russ.)
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