INCIDENCE AND FEATURES OF CLINICAL COURSE OF UPPER GASTROINTESTINAL TRACT DISEASES AND METABOLIC SYNDROME IN IBD PATIENTS

The purpose of the review: to observe prevalence and features of such comorbidities as gastroesophageal reflux disease, nonalcoholic fatty liver disease, metabolic syndrome and it’s components in patients with inflammatory bowel diseases (IBD). Methods: as literature sources databases Pubmed and Medscape were used, also data from monographies and Russian and foreign journal publications was included. Results: Higher frequency of steatohepatosis in IBD patients and higher frequency of gallstones in patients with Crohn’s disease (CD) are demonstrated. A risk factors of this comorbid diseases are described. Also lower frequency of arterial hypertension among IBD patients was shown. Higher frequency of metabolic syndrome in patients with ulcerous colitis vs. patients with CD was demonstrated. Higher severity of gastroesophageal reflux symptoms in IBD patients vs. patients with irritable bowel syndrome was shown. Article describes possible pathophysiological substrate of this clinical features. Conclusion. Frequency and clinical features of described comorbidities were analyzed. Literature analysis showed a lack of data about clinical features of gastroesophageal reflux disease and metabolic syndrome in IBD patients at this moment, so an additional studies on this subject are necessary.

Inflammatory bowel diseases, ulcerous colitis, Crohn’s disease, metabolic syndrome, arterial hypertension, obesity, steatohepatosis, GERD, gallstones, comorbid diseases

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