ACUTE NOROVIRUS GASTROENTERITIS IN ADULTS

The aim of this study was to determine the frequency and the clinical and laboratory features of norovirus acute gastroenteritis (AGE) in adult hospitalized patients, the residents of city Novosibirsk. Materials and methods: A total of 1047 patients aged 15 to 89 years who were hospitalized with AGE from January 2016 to April 2017 with no evidence of immunosuppression were examined. Together with conventional diagnostic methods, the polymerase chain reaction method with a set of original specific primers was also used to investigate feces for the presence of group A and group C rotaviruses, norovirus genogroup II (HNoV GII) and astroviruses. Results: Viral etiology was determined in 20.8 % of patients with AGE. HNoV GII was the dominant (13.6 %), followed by group A rotavirus (5.3 %) and astroviruses (2.0 %). HNoV GII dominance was observed in most months of the study period. For HNoV GII enteritis, a high incidence (p<0.05) of moderate fever and lymphocytosis is established in comparison with other AGE. Conclusion: The established frequency of viral AGE in adults shows the need to develop and implement in clinical practice universal test systems for detection of the most common viral pathogens. The predominance of HNoV GII in the structure of viral diarrhea aims further research on the genetic diversity of the isolates circulating in the Novosibirsk region.

acute viral gastroenteritis, norovirus, rotavirus, astrovirus, clinical and laboratory features, polymerase chain reaction

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