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INFLAMMATORY BOWEL DISEASE AND PREGNANCY: FROM WORLD EXPERIENCE TO OWN OBSERVATIONS

Abstract

Inflammatory bowel diseases (IBD) are an actual problem of reproductive medicine, and the care of women in childbearing age suffering from IBD has a high medical and social significance. The main peak of incidence of IBD falls on the age of 20-40 years, when childbirth is planned. Questions that need to be addressed and discussed in patients with IBD: is it possible for the normal course of pregnancy with IBD, how does the IBD affect pregnancy, what medications are contraindicated and others. The article presents and discusses theoretical aspects and practical issues related to pregnancy management, IBD therapy in the period of preparation to pregnancy, during pregnancy, in the postpartum period, the effectiveness and safety of pharmacotherapy in patients of this category is discussed.

About the Authors

M. I. Skalinskaya
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation


I. G. Bakulin
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation


T. N. Zhigalova
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation


E. V. Skazyvaeva
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation


S. I. Sitkin
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation


A. A. Kamensky
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation


References

1. Бакулин И. Г. К вопросу о распространенности и заболеваемости воспалительными заболеваниями кишечника в Москве / Бакулин И. Г., Шкурко Т. В., Парфенов А. И., Князев О. В., Фадеева Н. А., Жулина Е. Ю., Болдырева О. Н., Алиев Э. И. // Фарматека. - 2016. - № 2 (315). - С. 69-73.

2. Бакулин И. Г. Индексы активности - объективные критерии оценки степени тяжести язвенного колита / Бакулин И. Г. Станке Д. А., Белоусова Е. А., Головенко О. В., Михайлова Т. Л. // Экспериментальная и клинич. гастроэнтерология. - 2008. - № 6. - С. 14-16.

3. Регистр воспалительных заболеваний кишечника в г. Новосибирске: итоги 2016 / Осипенко М. Ф., Валуйских Е. Ю., Светлова И. О., Кулыгина Ю. А., Скалинская М. И., Бикбулатова Е. А., Краснер Я. А. // Сибирский научный медицинский журнал. 2017. Т. 37. № 1. С. 61-67.

4. D. Simian, D. Fluxá, L. Flores, J. Lubascher, P. Ibáñez, C. et al. Inflammatory bowel disease: A descriptive study of 716 local Chilean patients. World J Gastroenterol. 2016 June 14, 22 (22), С. 5267-5275.

5. The Second European Evidenced-Based Consensus on Reproduction and Pregnancy in Inflammatory Bowel Disease C. J. van der Woude, C.J. van der Woude Corresponding author: C. Janneke van der Woude, Erasmus MC, Department of Gastroenterology and Hepatology, for the European Crohn’s and Colitis Organization (ECCO) / for the European Crohn’s and Colitis Organization (ECCO)/Published: 16 January 2015.

6. Third European Evidence-Based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders / Magro F, Gionchetti P, at al. 2017 Feb 2.

7. Matthew Pinder, Katie Lummis, Christian P. Selinger / Managing inflammatory bowel disease in pregnancy: current perspectives Matthew Pinder, Katie Lummis, Christian P Selinger // Clin Exp Gastroenterol. - 2016; 9: 325-335.

8. Pedersen N., Bortoli A., Duricova D., et al. // The course of inflammatory bowel disease during pregnancy and postpartum: a prospective European ECCO-EpiCom Study of 209 pregnant women. Aliment Pharmacol Ther. 2013;38(5):501-512.

9. Rajaratnam SG, Eglinton TW, Hider P, Fearnhead NS. Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review. Int J Colorectal Dis. 2011;26(11):1365-1374.

10. Dubinsky M., Mahadevan U, Vermeire S, Abhyankar B, Lasch K. Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease; Poster presented at: Clinical: Therapy & Observation; European Crohns and Colitis Organisation; Barcelona: 2015.

11. Schulze H, Esters P / Editorial: the management of IBD during pregnancy and lactation - author’s reply / Schulze H, Esters P, Dignass A. //Aliment Pharmacol Ther. 2014 Nov;40(10):1248. doi: 10.1111/apt.12971

12. Minami N, Matsuura M, Koshikawa Y, Yamada S, Maternal and fetal outcomes in pregnant Japanese women with inflammatory bowel disease: our experience with a series of 23 cases // Aliment Pharmacol Ther. 2017 Apr;45(7):941-950. doi: 10.1111/apt.13960. Epub 2017 Feb 7.

13. Mahadevan U, Vermeire S / Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease // Aliment Pharmacol Ther. - 2017 Apr;45(7):941-950. doi: 10.1111/apt.13960. Epub 2017 Feb 7.

14. Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reprod Toxicol. 2008;25:271-275.

15. Tegethoff M, Pryce C, Meinlschmidt G. Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans: a systematic review. Endocr Rev. 2009;30:753-789

16. Beaulieu D. B., Ananthakrishnan A. N., Issa M., Rosenbaum L., Skaros S., Newcomer J. R., Kuhlmann R. S., Otterson M. F., Emmons J., Knox J., et al. Budesonide induction and maintenance therapy for Crohn’s disease during pregnancy. Inflamm. Bowel. Dis. 2009;15:25-28.

17. Dignass, A. Once versus three times daily dising of oral budesonide for active Crohn’s disease: double-blind, dоuble-dummy, randomised trial / Dignass A., Stoynov S., Dorofeyev A. E., Grigorieva G. A., Tomsová E., Altorjay I., Tuculanu D., Bunganič I., Pokrotnieks J., Kupčinskas L., Dilger K., Greinwald R., Mueller R., Penchev P., Kadian H., Petrov A., Chavushian A., Balabanska R., Tsonev R., Kurktschiev D. et al. // Journal of Crohns & Colitis. 2014. - Т. 8. № 9. - С. 970-980.

18. Komaki F, Komaki Y, Micic D, Ido A, Sakuraba А. / Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-α use in females with immune mediated diseases; a systematic review and meta-analysis. // J. Autoimmun. 2017 Jan;76:38-52. Epub. 2016 Nov 30.

19. Kammerlander H, Nielsen J, Kjeldsen J, Knudsen T, Friedman S, Nørgård B. The Effect of Disease Activity on Birth Outcomes in a Nationwide Cohort of Women with Moderate to Severe Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 Mar 24. doi: 10.1097/MIB.0000000000001102.


Review

For citations:


Skalinskaya M.I., Bakulin I.G., Zhigalova T.N., Skazyvaeva E.V., Sitkin S.I., Kamensky A.A. INFLAMMATORY BOWEL DISEASE AND PREGNANCY: FROM WORLD EXPERIENCE TO OWN OBSERVATIONS. Experimental and Clinical Gastroenterology. 2017;(7):184-191. (In Russ.)

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ISSN 1682-8658 (Print)