ASSESSMENT OF BONE MINERALIZATION AND BONE METABOLISM IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE
Abstract
Objectives: The aim of our study was to evaluate bone mineralization and metabolism in children with Crohn’s Disease (CD) and ulcerative colitis (UC). Material and methods: 113 patients with inflammatory bowel disease (IBD) (2-17 years) and 40 healthy children were included in the present study. We assessed markers of IBD activity. Bone mineral density (BMD) of lumbar spine (DEXA), serum osteocalcin (OC), C-terminal telopeptides (CTT), parathyroid hormone (PTH), serum calcium, alkaline phosphatase and 25 (OH) vitamin D were measured. Results: BMD in patients with CD and UC were lower than in control group (Zscore -1,4 SD, -1,3 SD and 0,31 SD, p=0,00001, respectively). Differences in level of PTH (39,4 pg/ml, 41,7 pg/ml и 24,8 pg/ml, p=0,04), and CTT (1,09 pg/ml, 1,08 pg/ml, 0,84 ng/ml, p=0,03) between CD, UC and healthy patients respectively have been found. There were no differences in serum OC between groups. Positive correlation between BMD and albumin, OC concentration and linear growth have been detected. IBD activity and duration, cumulative steroid dose were negatively associated with BMD. Vitamin D deficiency was observed in 98 % and 94,1 % of children with CD and UC respectively. Conclusions: patients IBD have low bone mineral density with increased bone resorption due to systemic inflammation, steroids side effect, vitamin D and calcium deficiency.
About the Authors
T. V. Gabrusskaya
Saint-Petersburg state pediatric medical University
Russian Federation
Russian Federation
M. O. Revnova
Saint-Petersburg state pediatric medical University
Russian Federation
Russian Federation
D. A. Kuzmina
North-Western state medical University n. a. I. I. Mechnikov
Russian Federation
Russian Federation
M. M. Kostik
Saint-Petersburg state pediatric medical University
Russian Federation
Russian Federation
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Gabrusskaya T.V., Revnova M.O., Kuzmina D.A., Kostik M.M. ASSESSMENT OF BONE MINERALIZATION AND BONE METABOLISM IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE. Experimental and Clinical Gastroenterology. 2017;(7):71-81. (In Russ.)
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