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Experimental and Clinical Gastroenterology

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JOG DIAGNOSTICS TYROSINEMIYA TYPE 1 IN CHILDREN AND EVALUATE THE EFFECTIVENESS OF SPECIFIC THERAPY

Abstract

Introduction: tyrosinemia type I - is a rare genetic disease that leads to cirrhosis of the liver, liver failure, and tubulopathy. In this connection, great importance is early diagnosis and timely initiation of pathogenetic treatment of the disease. Goal. Based on multivariate statistical analysis of clinical diagnostic indicators and their changes over time to develop an algorithm stepwise diagnosis of hereditary tyrosinemia type I in children and to evaluate the effectiveness of pathogenetic therapy. The scope and methods. The study included 17 children (8 boys and 9 girls) with tyrosinemia type I: 5 patients (29.4%) with type IA and 12 patients (70.6%) with the IB type. All children received pathogenetic therapy of NTBC. Conducted the study of history and the life of the patients of the disease, we evaluated the clinical and laboratory data at the onset of the disease and on the background of a six-month course of pathogenetic therapy. Results. Using multivariate statistical analysis revealed clinical and laboratory criteria for diagnosis of tyrosinemia type 1 in young children, followed by incremental compilation disease diagnostic algorithm. The estimation of the severity of liver dysfunction before and 6 months after initiation of specific therapy, which has proven its improvement.

About the Authors

G. V. Volynets
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


A. K. Gevorkyan
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


T. V. Bushueva
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


A. V. Nikitin
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


T. A. Skvortsova
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


A. I. Khavkin
Research Institute of Clinical Pediatrics Russian National Research Medical Pirogov University
Russian Federation


A. G. Ilin
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


S. R. Konova
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


A. S. Karulina
Russian National Research Medical University (RNRMU)
Russian Federation


A. S. Potapov
Federal State Budgetary Institution «Scientific Center of Children’s Health» Of the Ministry of Health of the Russian Federation
Russian Federation


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Review

For citations:


Volynets G.V., Gevorkyan A.K., Bushueva T.V., Nikitin A.V., Skvortsova T.A., Khavkin A.I., Ilin A.G., Konova S.R., Karulina A.S., Potapov A.S. JOG DIAGNOSTICS TYROSINEMIYA TYPE 1 IN CHILDREN AND EVALUATE THE EFFECTIVENESS OF SPECIFIC THERAPY. Experimental and Clinical Gastroenterology. 2017;(1):58-64. (In Russ.)

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ISSN 1682-8658 (Print)